ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries

Details

• Alternative Title:
  Transl Psychiatry
• Personal Author:
  Thompson, Paul M. ; Jahanshad, Neda ; Ching, Christopher R. K. ; Salminen, Lauren E. ; Thomopoulos, Sophia I. ; Bright, Joanna ; Baune, Bernhard T. ; Bertolín, Sara ; Bralten, Janita ; Bruin, Willem B. ; Bülow, Robin ; Chen, Jian ; Chye, Yann ; Dannlowski, Udo ; de Kovel, Carolien G. F. ; Donohoe, Gary ; Eyler, Lisa T. ; Faraone, Stephen V. ; Favre, Pauline ; Filippi, Courtney A. ; Frodl, Thomas ; Garijo, Daniel ; Gil, Yolanda ; Grabe, Hans J. ; Grasby, Katrina L. ; Hajek, Tomas ; Han, Laura K. M. ; Hatton, Sean N. ; Hilbert, Kevin ; Ho, Tiffany C. ; Holleran, Laurena ; Homuth, Georg ; Hosten, Norbert ; Houenou, Josselin ; Ivanov, Iliyan ; Jia, Tianye ; Kelly, Sinead ; Klein, Marieke ; Kwon, Jun Soo ; Laansma, Max A. ; Leerssen, Jeanne ; Lueken, Ulrike ; Nunes, Abraham ; Neill, Joseph O’ ; Opel, Nils ; Piras, Fabrizio ; Piras, Federica ; Postema, Merel C. ; Pozzi, Elena ; Shatokhina, Natalia ; Soriano-Mas, Carles ; Spalletta, Gianfranco ; Sun, Daqiang ; Teumer, Alexander ; Tilot, Amanda K. ; Tozzi, Leonardo ; van der Merwe, Celia ; Van Someren, Eus J. W. ; van Wingen, Guido A. ; Völzke, Henry ; Walton, Esther ; Wang, Lei ; Winkler, Anderson M. ; Wittfeld, Katharina ; Wright, Margaret J. ; Yun, Je-Yeon ; Zhang, Guohao ; Zhang-James, Yanli ; Adhikari, Bhim M. ; Agartz, Ingrid ; Aghajani, Moji ; Aleman, André ; Althoff, Robert R. ; Altmann, Andre ; Andreassen, Ole A. ; Baron, David A. ; Bartnik-Olson, Brenda L. ; Marie Bas-Hoogendam, Janna ; Baskin-Sommers, Arielle R. ; Bearden, Carrie E. ; Berner, Laura A. ; Boedhoe, Premika S. W. ; Brouwer, Rachel M. ; Buitelaar, Jan K. ; Caeyenberghs, Karen ; Cecil, Charlotte A. M. ; Cohen, Ronald A. ; Cole, James H. ; Conrod, Patricia J. ; De Brito, Stephane A. ; de Zwarte, Sonja M. C. ; Dennis, Emily L. ; Desrivieres, Sylvane ; Dima, Danai ; Ehrlich, Stefan ; Esopenko, Carrie ; Fairchild, Graeme ; Fisher, Simon E. ; Fouche, Jean-Paul ; Francks, Clyde ; Frangou, Sophia ; Franke, Barbara ; Garavan, Hugh P. ; Glahn, David C. ; Groenewold, Nynke A. ; Gurholt, Tiril P. ; Gutman, Boris A. ; Hahn, Tim ; Harding, Ian H. ; Hernaus, Dennis ; Hibar, Derrek P. ; Hillary, Frank G. ; Hoogman, Martine ; Hulshoff Pol, Hilleke E. ; Jalbrzikowski, Maria ; Karkashadze, George A. ; Klapwijk, Eduard T. ; Knickmeyer, Rebecca C. ; Kochunov, Peter ; Koerte, Inga K. ; Kong, Xiang-Zhen ; Liew, Sook-Lei ; Lin, Alexander P. ; Logue, Mark W. ; Luders, Eileen ; Macciardi, Fabio ; Mackey, Scott ; Mayer, Andrew R. ; McDonald, Carrie R. ; McMahon, Agnes B. ; Medland, Sarah E. ; Modinos, Gemma ; Morey, Rajendra A. ; Mueller, Sven C. ; Mukherjee, Pratik ; Namazova-Baranova, Leyla ; Nir, Talia M. ; Olsen, Alexander ; Paschou, Peristera ; Pine, Daniel S. ; Pizzagalli, Fabrizio ; Rentería, Miguel E. ; Rohrer, Jonathan D. ; Sämann, Philipp G. ; Schmaal, Lianne ; Schumann, Gunter ; Shiroishi, Mark S. ; Sisodiya, Sanjay M. ; Smit, Dirk J. A. ; Sønderby, Ida E. ; Stein, Dan J. ; Stein, Jason L. ; Tahmasian, Masoud ; Tate, David F. ; Turner, Jessica A. ; van den Heuvel, Odile A. ; van der Wee, Nic J. A. ; van der Werf, Ysbrand D. ; van Erp, Theo G. M. ; van Haren, Neeltje E. M. ; van Rooij, Daan ; van Velzen, Laura S. ; Veer, Ilya M. ; Veltman, Dick J. ; Villalon-Reina, Julio E. ; Walter, Henrik ; Whelan, Christopher D. ; Wilde, Elisabeth A. ; Zarei, Mojtaba ; Zelman, Vladimir
• Corporate Authors:
  for the ENIGMA Consortium
• Description:
  This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying the human brain in health and disease. Building on large-scale genetic studies that discovered the first robustly replicated genetic loci associated with brain metrics, ENIGMA has diversified into over 50 working groups (WGs), pooling worldwide data and expertise to answer fundamental questions in neuroscience, psychiatry, neurology, and genetics. Most ENIGMA WGs focus on specific psychiatric and neurological conditions, other WGs study normal variation due to sex and gender differences, or development and aging; still other WGs develop methodological pipelines and tools to facilitate harmonized analyses of "big data" (i.e., genetic and epigenetic data, multimodal MRI, and electroencephalography data). These international efforts have yielded the largest neuroimaging studies to date in schizophrenia, bipolar disorder, major depressive disorder, post-traumatic stress disorder, substance use disorders, obsessive-compulsive disorder, attention-deficit/hyperactivity disorder, autism spectrum disorders, epilepsy, and 22q11.2 deletion syndrome. More recent ENIGMA WGs have formed to study anxiety disorders, suicidal thoughts and behavior, sleep and insomnia, eating disorders, irritability, brain injury, antisocial personality and conduct disorder, and dissociative identity disorder. Here, we summarize the first decade of ENIGMA's activities and ongoing projects, and describe the successes and challenges encountered along the way. We highlight the advantages of collaborative large-scale coordinated data analyses for testing reproducibility and robustness of findings, offering the opportunity to identify brain systems involved in clinical syndromes across diverse samples and associated genetic, environmental, demographic, cognitive, and psychosocial factors.
• Subjects:
  Biomarkers Genomics Neuroscience Psychiatric Disorders Review Article Scientific Community
• Source:
  Transl Psychiatry. 10
• Pubmed ID:
  32198361
• Pubmed Central ID:
  PMC7083923
• Document Type:
  Journal Article
• Funding:
  R21 NS107739/NS/NINDS NIH HHS/United States ; R01 MH116147/MH/NIMH NIH HHS/United States ; APP1103623/Department of Health ; National Health and Medical Research Council (NHMRC)/ ; WA1539/11-1/Deutsche Forschungsgemeinschaft (German Research Foundation)/ ; R01 DA047119/DA/NIDA NIH HHS/United States ; S10 OD023696/OD/NIH HHS/United States ; R01 EB015611/EB/NIBIB NIH HHS/United States ; APP1158127/Department of Health ; National Health and Medical Research Council (NHMRC)/ ; R21 MH116473/MH/NIMH NIH HHS/United States ; K01 HD091283/HD/NICHD NIH HHS/United States ; R01 MH085953/MH/NIMH NIH HHS/United States ; R01 MH111671/MH/NIMH NIH HHS/United States ; R01 NS107739/U.S. Department of Health & Human Services ; NIH ; National Institute of Neurological Disorders and Stroke (NINDS)/ ; S10 OD023696/CD/ODCDC CDC HHS/United States ; ER724/4-1/Deutsche Forschungsgemeinschaft (German Research Foundation)/ ; R01 MH117601/MH/NIMH NIH HHS/United States ; U01 MH108148/MH/NIMH NIH HHS/United States ; U54 EB020403/EB/NIBIB NIH HHS/United States ; R01 AG059874/AG/NIA NIH HHS/United States ; R56 AG058854/AG/NIA NIH HHS/United States
• Volume:
  10
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:fe4376905926e9e308b47b80d4e9f613e81d18dc58094471006d2a8734ba4b60
• Download URL:
  https://stacks.cdc.gov/view/cdc/88844/cdc_88844_DS1.pdf
• File Type:
  [PDF - 2.56 MB ]