Weight Change in Older Adults and Risk of Frailty

Details

• Alternative Title:
  J Frailty Aging
• Personal Author:
  Crow, Rebecca S. ; Petersen, Curtis L. ; Cook, Summer B. ; Stevens, Courtney J. ; Titus, Alexander J. ; Mackenzie, Todd A. ; Batsis, John A.
• Description:
  OBJECTIVE:
  
  A 5% change in weight is a significant predictor for frailty and obesity. We ascertained how self-reported weight change over the lifespan impacts rates of frailty in older adults.
  
  METHODS:
  
  We identified 4,984 subjects ≥60 years with body composition measures from the National Health and Nutrition Examination Survey. An adapted version of Fried’s frailty criteria was used as the primary outcome. Self-reported weight was assessed at time current,1 and 10 years earlier and at age 25. Weight changes between each time point were categorized as ≥ 5%, ≤5% or neutral. Logistic regression assessed the impact of weight change on the outcome of frailty.
  
  RESULTS:
  
  Among 4,984 participants, 56.5% were female, mean age was 71.1 years, and mean BMI was 28.2kg/m2. A weight loss of ≥ 5% had a higher association with frailty compared to current weight, age 25 (OR 2.94 [1.72,5.02]), 10 years ago (OR 1.68 [1.05,2.69]), and 1 year ago (OR 1.55 [1.02,2.36]). Weight gain in the last year was associated with increased rate of frailty (1.59 [1.09,2.32]).
  
  CONCLUSION:
  
  There is an association between frailty and weight loss over time while only weight gain in the last year has an association with frailty.
  
  
• Subjects:
  Aged Article Body-Weight Trajectory Female Frail Elderly Frailty Humans Male Middle Aged Nutrition Surveys Obesity Pre-frailty Sarcopenia Self Report

  More +
• Source:
  J Frailty Aging. 9(2):74-81
• Pubmed ID:
  32259180
• Pubmed Central ID:
  PMC7202674
• Document Type:
  Journal Article
• Funding:
  T32 MH073553/MH/NIMH NIH HHSUnited States/ ; P30 CA023108/CA/NCI NIH HHSUnited States/ ; U48 DP005018/DP/NCCDPHP CDC HHSUnited States/ ; U48DP005018/ACL/ACL HHSUnited States/ ; T32 LM012204/LM/NLM NIH HHSUnited States/ ; K23 AG051681/AG/NIA NIH HHSUnited States/ ; WT_/Wellcome TrustUnited Kingdom/
• Volume:
  9
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:d06e69d9b3b0db47bf912b44c108facb85080d3792fe062c88aef8caf38cfbd9
• Download URL:
  https://stacks.cdc.gov/view/cdc/87771/cdc_87771_DS1.pdf
• File Type:
  [PDF - 143.40 KB ]