Biphasic Outbreak of Invasive Group A Streptococcus Disease in Eldercare Facility, New Zealand

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Worthing, Kate A. ; Werno, Anja ; Pink, Ramon ; McIntyre, Liam ; Carter, Glen P. ; Williamson, Deborah A. ; Davies, Mark R.
• Description:
  A 3-month outbreak of invasive group A Streptococcus disease at an eldercare facility, in which 5 persons died, was biphasic. Although targeted chemoprophylaxis contained the initial outbreak, a second phase of the outbreak occurred after infection control processes ended. To retrospectively investigate the genomic epidemiology of the biphasic outbreak, we used whole-genome sequencing and multiple bioinformatics approaches. Analysis of isolates from the outbreak and isolates prospectively collected during the outbreak response indicated a single S. pyogenes emm81 clone among residents and staff members. Outbreak isolates differed from nonoutbreak emm81 isolates by harboring an integrative conjugative genomic element that contained the macrolide resistance determinant erm(TR). This study shows how retrospective high-resolution genomic investigations identified rapid spread of a closed-facilty clonal outbreak that was controlled, but not readily cleared, by infection control management procedures.
• Subjects:
  Antimicrobial Resistance Bacteria Biphasic Outbreak Of Invasive Group A Streptococcus Disease In Eldercare Facility, New Zealand Gas Genomic Epidemiology Group A Streptococcus Integrative Conjugative Element Invasive Disease Outbreak Macrolide Resistance New Zealand Outbreak Management Streptococci Streptococcus Pyogenes Synopsis

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• Source:
  Emerg Infect Dis. 26(5):841-848
• Pubmed ID:
  32308193
• Pubmed Central ID:
  PMC7181915
• Document Type:
  Journal Article
• Volume:
  26
• Issue:
  5
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:5135bbd38c8daee052227334c45c595fe9776e5e1055013c1ca837b2c9e7935a
• Download URL:
  https://stacks.cdc.gov/view/cdc/87648/cdc_87648_DS1.pdf
• File Type:
  [PDF - 1.42 MB ]