Assessing cancer treatment information using Medicare and hospital discharge data among women with non-Hodgkin lymphoma in a Los Angeles County case-control study

Details

• Alternative Title:
  Cancer Epidemiol Biomarkers Prev
• Personal Author:
  Zhong, Charlie ; Seibold, Petra ; Chao, Chun R. ; Cozen, Wendy ; Song, Joo Y. ; Weisenburger, Dennis ; Bernstein, Leslie ; Wang, Sophia S.
• Description:
  Background:
  
  We assessed the ability to supplement existing epidemiological/etiologic studies with data on treatment and clinical outcomes by linking to publicly available cancer registry and administrative databases.
  
  Methods:
  
  Medical records were retrieved and abstracted for cases enrolled in a Los Angeles County case-control study of non-Hodgkin Lymphoma(NHL). Cases were linked to the Los Angeles County cancer registry(CSP), the California state hospitalization discharge database(OSHPD), and the Surveillance, Epidemiology and End Results Registry(SEER)-Medicare database. We assessed sensitivity, specificity, and positive predictive value(PPV) of cancer treatment in linked databases, compared to medical record abstraction.
  
  Results:
  
  We successfully retrieved medical records for 918 of 1,004 participating NHL cases and abstracted treatment for 698. We linked 59% of cases(96% of cases >65 years old) to SEER-Medicare and 96% to OSHPD. Chemotherapy was the most common treatment and best captured, with the highest sensitivity in SEER-Medicare(80%) and CSP(74%); combining all three data sources together increased sensitivity(92%), at reduced specificity(56%). Sensitivity for radiotherapy was moderate; 77% with aggregated data. Sensitivity of BMT was low in the CSP(42%), but high for the administrative databases, especially OSHPD(98%). Sensitivity for surgery reached 83% when considering all three datasets in aggregate, but PPV was 60%. In general, sensitivity and PPV for chronic lymphocytic leukemia/small lymphocytic lymphoma(CLL/SLL) were low.
  
  Conclusions:
  
  Chemotherapy was accurately captured by all data sources. Hospitalization data yielded the highest performance values for BMTs. Performance measures for radiotherapy and surgery were moderate.
  
  Impact:
  
  Various administrative databases can supplement epidemiological studies depending on treatment type and NHL subtype of interest.
  
  
• Subjects:
  Administrative Claims, Healthcare Adult Aged Case-Control Studies Data Mining Drug Therapy Electronic Health Records Female Humans Incidence Los Angeles Lymphoma, Non-Hodgkin Medicare Middle Aged Patient Discharge Radiotherapy SEER Program Sensitivity And Specificity Surgical Procedures, Operative United States Young Adult

  More +
• Keywords:
  Administrative Databases Buprenorphine Cancer Registry Cancer Treatment Case-control Study Methadone Mortality Naltrexone Non-Hodgkin Lymphoma Treatment
• Source:
  Cancer Epidemiol Biomarkers Prev. 29(5):936-941
• Pubmed ID:
  32066614
• Pubmed Central ID:
  PMC7196521
• Document Type:
  Journal Article
• Funding:
  R01 CA166219/CA/NCI NIH HHSUnited States/ ; HHSN261201000035C/CA/NCI NIH HHSUnited States/ ; HHSN261201000035I/CA/NCI NIH HHSUnited States/ ; HHSN261201000034C/CA/NCI NIH HHSUnited States/ ; P01 CA017054/CA/NCI NIH HHSUnited States/ ; HHSN261201000140C/CA/NCI NIH HHSUnited States/ ; R01 CA108634/CA/NCI NIH HHSUnited States/ ; U58 DP003862/DP/NCCDPHP CDC HHSUnited States/ ; P30 CA033572/CA/NCI NIH HHSUnited States/
• Volume:
  29
• Issue:
  5
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:82ee1b97b14e03b0fc2e24554b75be0ac2c1d718f34552d5fe0a73f75d8aa8c059a43669e6c865dfb4f2fcd4e9f4ee7f72ded60630f8cbfca1d2169ec91abe1d
• Download URL:
  https://stacks.cdc.gov/view/cdc/87617/cdc_87617_DS1.pdf
• File Type:
  [PDF - 331.91 KB ]