Details:

Alternative Title:
AIDS Care
Personal Author:
Brooks, Richard B. ; Feldman, Katherine A. ; Blythe, David ; Flynn, Colin
Brooks, Richard B. ; Feldman, Katherine A. ; Blythe, David ; Flynn, Colin Less -
Description:
HIV nucleotide sequences generated through routine drug resistance testing (DRT) and reported to Maryland's Molecular HIV Surveillance system are most effective for elucidating transmission patterns and identifying outbreaks if DRT is ordered promptly and sequences are reported completely. Among reported cases of HIV infection newly diagnosed during 2011-2013 in Maryland residents aged ≥13 years, we assessed sequence ascertainment completeness. To better understand which populations were most likely to have a sequence, we examined associations between sequence ascertainment and clinical and demographic characteristics. During 2011-2013, 4423 new HIV infection diagnoses were reported; sequences were ascertained for 1282 (29.0%). Among 3267 cases with complete data, odds for having a sequence ascertained were highest for cases in persons living inside Maryland's Central Region with initial CD4 counts ≤500 cells/mm| (adjusted odds ratio [aOR] 2.4, 95% confidence interval [CI] 1.9-3.1). Sequence ascertainment did not vary significantly by patient age, sex, race/ethnicity or HIV transmission category. Educational interventions, policy changes and improved processes to increase timely DRT and subsequent sequence reporting with a focus on testing at entry to care, particularly for those with higher CD4 counts and those living outside the Central Region, might improve ascertainment completeness.
Subjects:
[+]
Adolescent Adult Anti-HIV Agents CD4 Lymphocyte Count Drug Resistance, Viral Female HIV-1 HIV Infections Humans Male Mass Screening Middle Aged Nucleotides Odds Ratio Population Surveillance
Source:
AIDS Care. 31(5):621-628
Pubmed ID:
30430842
Pubmed Central ID:
PMC6786757
Document Type:
Journal Article
Funding:
CC999999/ImCDC/Intramural CDC HHS/United States
Place as Subject:
Maryland
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:dfa3c863cde75046b85f6fac7bfb17d83f2e2350c308e26720c5c7530454f9c3
Download URL:
https://stacks.cdc.gov/view/cdc/87420/cdc_87420_DS1.pdf
File Type:

Supporting Files

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