Details:

Alternative Title:
Birth Defects Res
Personal Author:
Tinker, Sarah C. ; Reefhuis, Jennita ; Bitsko, Rebecca H. ; Gilboa, Suzanne M. ; Mitchell, Allen A. ; ... More +
Tinker, Sarah C. ; Reefhuis, Jennita ; Bitsko, Rebecca H. ; Gilboa, Suzanne M. ; Mitchell, Allen A. ; Tran, Emmy L. ; Werler, Martha M. ; Broussard, Cheryl S. ; Less -
Description:
Background Benzodiazepine medications can be used to treat anxiety, a condition affecting 15% of women of childbearing age in the United States. Studies have shown conflicting results for the association between benzodiazepine use during pregnancy and birth defects. Methods We analyzed 1997–2011 data from the National Birth Defects Prevention Study, a multisite, population-based case–control study. We assessed the prevalence of and factors associated with benzodiazepine use in pregnancy among mothers of live-born infants without a birth defect (control mothers). We used logistic regression to estimate adjusted odds ratios (aORs) and 95% confidence intervals (CIs) for the association between specific birth defects and benzodiazepine use; we estimated crude odds ratios (cORs) for defect categories with 3–4 exposed cases. Results Exposure to benzodiazepines during pregnancy was rare (N = 93/11,614; 0.8%). Benzodiazepine use was more common among control mothers who were ≥30 years, non-Hispanic white, had more education, smoked, and took antidepressant medication. We observed significantly elevated ORs for any benzodiazepine and Dandy–Walker malformation (cOR: 3.1; 95% CI: 1.1, 8.6); for alprazolam and anophthalmia or microphthalmia (cOR: 4.0; 95% CI: 1.2, 13.1) and esophageal atresia or stenosis (aOR: 2.7; 95% CI: 1.2, 5.9); and lorazepam and pulmonary valve stenosis (cOR: 4.1; 95% CI: 1.2, 14.2), but sample sizes were limited and therefore CIs were wide. Conclusions Our findings suggest that benzodiazepines use is rare and may be associated with risk for certain birth defects. However, these results need replication and should be interpreted with caution.
Subject:
[+]
Abnormalities, Drug-Induced
Adolescent
Adult
Article
Benzodiazepine
Benzodiazepines
Birth Defect
Case-Control Studies
Congenital Abnormalities
Female
Humans
Infant, Newborn
Logistic Models
Medication
Mothers
Odds Ratio
Pregnancy
Prenatal Exposure Delayed Effects
Risk Factors
Young Adult
Pregnancy

Source:
Birth Defects Res. 111(10):613-620 ;
Pubmed ID:
30891943
Pubmed Central ID:
PMC7186570
Document Type:
Journal Article ;
Funding:
CC999999/ImCDC/Intramural CDC HHS/United States ; U01 DD001224/DD/NCBDD CDC HHS/United States ;
CC999999/ImCDC/Intramural CDC HHS/United States ; U01 DD001224/DD/NCBDD CDC HHS/United States ; Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:c58c795da132c70c465f2bd5fbf01ce30f42766c76d845e421864192e3ea146d
File Type:

Supporting Files

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  	nihms-1577361-f0001.jpg	jpeg
  	nihms-1577361.nxml	xml
  	NIHMS1577361-supplement-Supp_Tables.docx	docx

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