Streptococcus pyogenes pbp2x Mutation Confers Reduced Susceptibility to β-Lactam Antibiotics

Details

• Journal Article:
  Clin Infect Dis
• Personal Author:
  Vannice, Kirsten S. ; Ricaldi, Jessica ; Nanduri, Srinivas ; Fang, Ferric C. ; Lynch, John B. ; Bryson-Cahn, Chloe ; Wright, Theodore ; Duchin, Jeff ; Kay, Meagan ; Chochua, Sopio ; Van Beneden, Chris A. ; Beall, Bernard
• Description:
  Two near-identical clinical Streptococcus pyogenes isolates of emm subtype emm43.4 with a pbp2x missense mutation (T553K) were detected. Minimum inhibitory concentrations (MICs) for ampicillin and amoxicillin were 8-fold higher, and the MIC for cefotaxime was 3-fold higher than for near-isogenic control isolates, consistent with a first step in developing β-lactam resistance.
• Subjects:
  Anti-Bacterial Agents Beta-Lactam Resistance Humans Microbial Sensitivity Tests Mutation Penicillin-Binding Proteins Streptococcus Pyogenes
• Keywords:
  Antimicrobial Resistance Group A Streptococcus β-lactam Resistance
• Source:
  Clin Infect Dis. 71(1):201-204
• DOI:
  http://dx.doi.org/10.1093/cid/ciz1000
• Pubmed ID:
  31630171
• Pubmed Central ID:
  PMC7167332
• Document Type:
  Text ; Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Genre:
  Journal Article
• Volume:
  71
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:2ed6953a4aa6a8cf8bcced154d0775a9dde9966bf30a39293700609de60c25432ed161a3f6217a022240d606468c36a8323b89de2cb7f0fdb8edc6f7b53131a0
• Download URL:
  https://stacks.cdc.gov/view/cdc/87055/cdc_87055_DS1.pdf
• File Type:
  [PDF - 365.88 KB ]