Streptococcus pyogenes pbp2x Mutation Confers Reduced Susceptibility to β-Lactam Antibiotics

Vannice, Kirsten S.; Ricaldi, Jessica; Nanduri, Srinivas; Fang, Ferric C.; Lynch, John B.; Bryson-Cahn, Chloe; Wright, Theodore; Duchin, Jeff; Kay, Meagan; Chochua, Sopio; Van Beneden, Chris A.; Beall, Bernard

doi:10.1093/cid/ciz1000

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CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners. As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.

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Streptococcus pyogenes pbp2x Mutation Confers Reduced Susceptibility to β-Lactam Antibiotics

6 24 2020
By Vannice, Kirsten S. ; Ricaldi, Jessica ; Nanduri, Srinivas ; ...
http://dx.doi.org/10.1093/cid/ciz1000
Source: Clin Infect Dis. 71(1):201-204

[PDF-365.88 KB]

English

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Details:

Alternative Title:

Clin Infect Dis
Personal Author:

Vannice, Kirsten S. ; Ricaldi, Jessica ; Nanduri, Srinivas ; Fang, Ferric C. ; Lynch, John B. ; ... More +

Vannice, Kirsten S. ; Ricaldi, Jessica ; Nanduri, Srinivas ; Fang, Ferric C. ; Lynch, John B. ; Bryson-Cahn, Chloe ; Wright, Theodore ; Duchin, Jeff ; Kay, Meagan ; Chochua, Sopio ; Van Beneden, Chris A. ; Beall, Bernard Less -
Description:

Two near-identical clinical Streptococcus pyogenes isolates of emm subtype emm43.4 with a pbp2x missense mutation (T553K) were detected. Minimum inhibitory concentrations (MICs) for ampicillin and amoxicillin were 8-fold higher, and the MIC for cefotaxime was 3-fold higher than for near-isogenic control isolates, consistent with a first step in developing β-lactam resistance.
Subjects:

[+]

Anti-Bacterial Agents Beta-Lactam Resistance Humans Microbial Sensitivity Tests Mutation Penicillin-Binding Proteins Streptococcus Pyogenes
Keywords:

[+]

Antimicrobial Resistance Group A Streptococcus β-lactam Resistance
Source:

Clin Infect Dis. 71(1):201-204
Pubmed ID:

31630171
Pubmed Central ID:

PMC7167332
Document Type:

Journal Article
Funding:

CC999999/ImCDC/Intramural CDC HHSUnited States/
Volume:

71
Issue:

1
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:0f9514abb42e6b7001b123aaea5b55fba54c643a0096729ea87a32eb0430b572
Download URL:

https://stacks.cdc.gov/view/cdc/87055/cdc_87055_DS1.pdf
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