Manganese is associated with increased plasma interleukin-1β during pregnancy, within a mixtures analysis framework of urinary trace metals

Aung, Max T.; Meeker, John D.; Boss, Jonathan; Bakulski, Kelly M.; Mukherjee, Bhramar; Cantonwine, David E.; McElrath, Thomas F.; Ferguson, Kelly K.

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Manganese is associated with increased plasma interleukin-1β during pregnancy, within a mixtures analysis framework of urinary trace metals

Published Date:

December 24 2019

Source:

Reprod Toxicol. 93:43-53

Language:

English

Public Access Version Available on: April 01, 2021, 12:00 AM

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Details:

Alternative Title:

Reprod Toxicol

Personal Author:

Aung, Max T. ; Meeker, John D. ; Boss, Jonathan ; Bakulski, Kelly M. ; Mukherjee, Bhramar ; ... More ▼

Description:

Exposure to trace metals may impact reproductive health outcomes through perturbations in maternal immune signaling molecules. We conducted a cross-sectional study of 390 pregnant women from the LIFECODES birth cohort and investigated the associations between 17 urinary metals and five immune biomarkers measured in the 3rd trimester (median 26 weeks gestation). We used linear regression to estimate pair-wise associations and applied elastic net and Bayesian kernel machine regression to identify important contributing exposures analytes as well as non-linear effects. Maternal urinary manganese, nickel, and barium were positively associated with maternal plasma interleukin-1β (IL-1β). Elastic net and Bayesian kernel machine regression identified manganese as the dominant trace metal in association with IL-1β. An interquartile range difference in manganese (0.6 μg/L) was associated with a 29 % increase in IL-1β (95 % CI: 12.4-48.2). In conclusion, trace metal exposures were associated with biomarkers of immune perturbations, and this warrants further investigation.

Subject:

[+]

Pubmed ID:

31881266

Pubmed Central ID:

PMC7138746

Document Type:

Journal Article

Funding:

P30 ES017885/ES/NIEHS NIH HHS/United States ; T42 OH008455/OH/NIOSH CDC HHS/United States ; R01 AG055406/AG/NIA NIH HHS/United States ;

Collection(s):

CDC Public Access

Main Document Checksum:

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Supporting Files:

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