Manganese is associated with increased plasma interleukin-1β during pregnancy, within a mixtures analysis framework of urinary trace metals

Details

• Alternative Title:
  Reprod Toxicol
• Personal Author:
  Aung, Max T. ; Meeker, John D. ; Boss, Jonathan ; Bakulski, Kelly M. ; Mukherjee, Bhramar ; Cantonwine, David E. ; McElrath, Thomas F. ; Ferguson, Kelly K.
• Description:
  Exposure to trace metals may impact reproductive health outcomes through perturbations in maternal immune signaling molecules. We conducted a cross-sectional study of 390 pregnant women from the LIFECODES birth cohort and investigated the associations between 17 urinary metals and five immune biomarkers measured in the 3rd trimester (median 26 weeks gestation). We used linear regression to estimate pair-wise associations and applied elastic net and Bayesian kernel machine regression to identify important contributing exposures analytes as well as non-linear effects. Maternal urinary manganese, nickel, and barium were positively associated with maternal plasma interleukin-1β (IL-1β). Elastic net and Bayesian kernel machine regression identified manganese as the dominant trace metal in association with IL-1β. An interquartile range difference in manganese (0.6 μg/L) was associated with a 29 % increase in IL-1β (95 % CI: 12.4-48.2). In conclusion, trace metal exposures were associated with biomarkers of immune perturbations, and this warrants further investigation.
• Subjects:
  Adolescent Adult Biological Monitoring Biomarkers Environmental Pollutants Female Fetus Humans Interleukin-1beta Male Metals Pregnancy Young Adult

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• Keywords:
  Cytokines Immune Perturbations Trace Metals
• Source:
  Reprod Toxicol. 93:43-53
• Pubmed ID:
  31881266
• Pubmed Central ID:
  PMC7138746
• Document Type:
  Journal Article
• Funding:
  T42 OH008455/OH/NIOSH CDC HHSUnited States/ ; U2C ES026553/ES/NIEHS NIH HHSUnited States/ ; R01 ES018872/ES/NIEHS NIH HHSUnited States/ ; P30 ES017885/ES/NIEHS NIH HHSUnited States/ ; R24 ES028533/ES/NIEHS NIH HHSUnited States/ ; ZIA ES103321-03/ImNIH/Intramural NIH HHSUnited States/ ; P42 ES017198/ES/NIEHS NIH HHSUnited States/ ; P50 ES026049/ES/NIEHS NIH HHSUnited States/
• Volume:
  93
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:11baefdbf0333729d7908e8acb0fb79193ac6a2049e209ee96971d70d7ac7eb5
• Download URL:
  https://stacks.cdc.gov/view/cdc/86604/cdc_86604_DS1.pdf
• File Type:
  [PDF - 1.31 MB ]