Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Chen, Yi-Yin ; Hsieh, Yu-Chia ; Gong, Yu-Nong ; Liao, Wei-Chao ; Li, Shiao-Wen ; ... More +
Chen, Yi-Yin ; Hsieh, Yu-Chia ; Gong, Yu-Nong ; Liao, Wei-Chao ; Li, Shiao-Wen ; Chang, Ian Yi-Feng ; Lin, Tzu-Lung ; Huang, Ching-Tai ; Chiu, Cheng-Hsiu ; Wu, Tsu-Lan ; Su, Lin-Hui ; Li, Ting-Hsuan ; Huang, Ya-Yu Less -
Description:
Incidence of invasive pneumococcal disease caused by antimicrobial-resistant Streptococcus pneumoniae types not included in pneumococcal conjugate vaccines has increased, including a penicillin- and meropenem-resistant serotype 15A-ST63 clone in Japan. During 2013-2017, we collected 206 invasive pneumococcal isolates in Taiwan for penicillin and meropenem susceptibility testing. We found serotypes 15B/C-ST83 and 15A-ST63 were the most prevalent penicillin- and meropenem-resistant clones. A transformation study confirmed that penicillin-binding protein (PBP) 2b was the primary meropenem resistance determinant, and PBP1a was essential for high-level resistance. The rate of serotype 15B/C-ST83 increased during the study. All 15B/C-ST83 isolates showed an ermB macrolide resistance genotype. Prediction analysis of recombination sites revealed 12 recombination regions in 15B/C-ST83 compared with the S. pneumoniae Spain|-ST81 genome. Pneumococcal clones rapidly recombine to acquire survival advantages and undergo local expansion under the selective pressure exerted by vaccines and antimicrobial drugs. The spread of 15B/C-ST83 is alarming for countries with high antimicrobial pressure.
Subjects:
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15B/C Amr Antimicrobial Resistance Bacteria Genome Sequencing Genomic Insight Into The Spread Of Meropenem-Resistant Streptococcus Pneumoniae Spain23F-St81, Taiwan Invasive Pneumococcal Disease Meningitis Meropenem Resistance Pcv-13 Pneumonia Research Sepsis Streptococcus Pneumoniae Taiwan
Source:
Emerg Infect Dis. 26(4):711-720
Pubmed ID:
32186492
Pubmed Central ID:
PMC7101100
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:c6e75528b91f0f7f571826071b3ab979f919f32be8545eee87f67a7f39cb51ae
Download URL:
https://stacks.cdc.gov/view/cdc/86469/cdc_86469_DS1.pdf
File Type:

Supporting Files

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