OleD Loki as a Catalyst for Hydroxamate Glycosylation

Hughes, Ryan R.; Shaaban, Khaled A.; Ponomareva, Larissa V.; Horn, Jamie; Zhang, Chunhui; Zhan, Chang-Guo; Voss, S. Randal; Leggas, Markos; Thorson, Jon S.

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OleD Loki as a Catalyst for Hydroxamate Glycosylation

Published Date:

November 26 2019

Source:

Chembiochem. 21(7):952-957

Language:

English

[PDF-714.05 KB]

Details:

Alternative Title:

Chembiochem

Personal Author:

Hughes, Ryan R. ; Shaaban, Khaled A. ; Ponomareva, Larissa V. ; Horn, Jamie ; Zhang, Chunhui ; ... More ▼

Description:

Herein we describe the ability of the permissive glycosyltransferase (GT) OleD Loki to convert a diverse set of >15 histone deacetylase (HDAC) inhibitors (HDACis) into their corresponding hydroxamate glycosyl esters. Representative glycosyl esters were subsequently evaluated in assays for cancer cell line cytotoxicity, chemical and enzymatic stability, and axolotl embryo tail regeneration. Computational substrate docking models were predictive of enzyme-catalyzed turnover and suggest certain HDACis may form unproductive, potentially inhibitory, complexes with GTs.

Subject:

[+]

Pubmed ID:

31621997

Pubmed Central ID:

PMC7124993

Document Type:

Journal Article

Funding:

R37 AI52218/GM/NIGMS NIH HHS/United States ; R24 OD21479/CD/ODCDC CDC HHS/United States ; UL1 TR000117/TR/NCATS NIH HHS/United States ; UL1 TR001998/TR/NCATS NIH HHS/United States ; R37 AI052218/AI/NIAID NIH HHS/United States ; ... More ▼

Collection(s):

CDC Public Access

Main Document Checksum:

[+]

File Type:

Supporting Files:

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OleD Loki as a Catalyst for Hydroxamate Glycosylation

OleD Loki as a Catalyst for Hydroxamate Glycosylation

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