Obesity and Risk for Second Malignant Neoplasms in Childhood Cancer Survivors: A Case-Control Study Utilizing the California Cancer Registry

Details

• Alternative Title:
  Cancer Epidemiol Biomarkers Prev
• Personal Author:
  Moke, Diana J. ; Hamilton, Ann S. ; Chehab, Leena ; Deapen, Dennis ; Freyer, David R.
• Description:
  Background:
  
  Obesity is a known modifiable risk factor associated with adverse outcomes in children with cancer. We sought to determine if obesity during childhood cancer treatment increases risk for second malignant neoplasms (SMNs).
  
  Methods:
  
  In this case-control study, cases (with SMN) and controls (with a single primary cancer) were selected from the California Cancer Registry who had primary cancer diagnosed <21 years treated at Children’s Hospital Los Angeles (CHLA) between 1988–2014. Controls were matched 3:1 to cases at the registry level by clinical factors. Medical records were abstracted for cancer treatment exposures, cancer predisposition syndrome, body mass index (BMI), BMI Z-score, and BMI category at diagnosis and EOT.
  
  Results:
  
  Fifty-nine cases and 130 controls were included. Median age at primary cancer diagnosis was 6 years, 64.5% were male, median time from primary cancer to SMN was 7.5 years, and 31.7% were obese or overweight. In matched multivariable analyses, there were elevated but non-significant associations between SMN and higher BMI Z-score at diagnosis (OR 1.27 [0.99–1.63]) and higher BMI categories at diagnosis (adjusted OR [aOR] overweight 1.25 [0.55–2.52]; aOR obese 2.51 [1.00–6.29]). There was a significantly increased risk for SMN among patients who were obese at both diagnosis and EOT (aOR 4.44 [1.37–14.34]).
  
  Conclusions:
  
  This study suggests obesity during childhood cancer treatment may be associated with increased risk for SMNs, particularly among those obese throughout therapy.
  
  Impact:
  
  Additional studies to confirm these findings and to develop interventions have the potential to impact SMN development in children with cancer.
  
  
• Subjects:
  Adolescent Adult Body Mass Index California Cancer Survivors Case-Control Studies Child Child, Preschool Female Humans Infant Male Neoplasms Neoplasms, Second Primary Obesity Overweight Registries Risk Factors Young Adult

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• Source:
  Cancer Epidemiol Biomarkers Prev. 28(10):1612-1620
• Pubmed ID:
  31337641
• Pubmed Central ID:
  PMC6774883
• Document Type:
  Journal Article
• Funding:
  HHSN261201800009C/CA/NCI NIH HHSUnited States/ ; NU58DP006344/DP/NCCDPHP CDC HHSUnited States/ ; T32 CA009659/CA/NCI NIH HHSUnited States/ ; HHSN261201800015I/CA/NCI NIH HHSUnited States/ ; HHSN261201800010I/CA/NCI NIH HHSUnited States/ ; UL1 TR001855/TR/NCATS NIH HHSUnited States/ ; HHSN261201800015C/CA/NCI NIH HHSUnited States/ ; HHSN261201800010C/CA/NCI NIH HHSUnited States/ ; HHSN261201800009I/CA/NCI NIH HHSUnited States/
• Volume:
  28
• Issue:
  10
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:c15607ee1af55831978d31abe7319ca94667a78ad29632aa320c5b334635531b4dbfb5039a988037472b9515e5b965e946970ddd793c9be634d24ab6a58edbb8
• Download URL:
  https://stacks.cdc.gov/view/cdc/86384/cdc_86384_DS1.pdf
• File Type:
  [PDF - 193.49 KB ]