Cancer Epidemiol Biomarkers Prev

Background Cancer incidence rates for American Indian and Alaska Native (AI/AN) populations vary by geographic region in the United States. The purpose of the present study is to examine cancer incidence rates and trends in the AI/AN population compared with the non-Hispanic white population in the United States for the years 2010–2015. Methods Cases diagnosed during 2010–2015 were identified from population-based cancer registries and linked with the Indian Health Service (IHS) patient registration databases to describe cancer incidence rates in non-Hispanic AI/AN persons compared to non-Hispanic whites (whites) living in IHS purchased/referred care delivery area counties. Age-adjusted rates were calculated for the 15 most common cancer sites, expressed per 100,000 per year. Incidence rates are presented overall as well as by region. Trends were estimated using joinpoint regression analyses. Results Lung and colorectal cancer incidence rates were nearly 20 percent to 2.5 times higher in AI/AN males and nearly 20 percent to nearly 3 times higher in AI/AN females compared to whites in the Northern Plains, Southern Plains, Pacific Coast and Alaska. Cancers of the liver, kidney and stomach were significantly higher in the AI/AN compared to the white population in all regions. We observed more significant decreases in cancer incidence rates in the white population compared to the AI/AN population. Conclusions Findings demonstrate the importance of examining cancer disparities between AI/AN and white populations. Disparities have widened for lung, female breast, and liver cancers. Impact These findings highlight opportunities for targeted public health interventions to reduce AI/AN cancer incidence.

31575554

PMC6777852

Journal Article

CC999999/ImCDC/Intramural CDC HHS/United States

United States

CDC Public Access