Details:

Alternative Title:
Cancer Epidemiol
Personal Author:
Panagopoulou, Paraskevi ; Skalkidou, Alkistis ; Marcotte, Erin ; Erdmann, Friederike ; Ma, Xiaomei ; ... More +
Panagopoulou, Paraskevi ; Skalkidou, Alkistis ; Marcotte, Erin ; Erdmann, Friederike ; Ma, Xiaomei ; Heck, Julia E ; Auvinen, Anssi ; Mueller, Beth A ; Spector, Logan G ; Roman, Eve ; Metayer, Catherine ; Magnani, Corrado ; Pombo-de-Oliveira, Maria S ; Scheurer, Michael E ; Mora, Ana M ; Dockerty, John D ; Hansen, Johnni ; Kang, Alice Y ; Wang, Rong ; Doody, David R ; Kane, Eleanor ; Schüz, Joachim ; Christodoulakis, Christos ; Ntzani, Evangelia ; Petridou, EleniTh Less -
Corporate Authors:
FRECCLE group ; NARECHEM-ST group
FRECCLE group ; NARECHEM-ST group Less -
Description:
Background:

Parental age has been associated with several childhood cancers, albeit the evidence is still inconsistent.

Aim:

To examine the associations of parental age at birth with acute myeloid leukemia (AML) among children aged 0-14 years using individual-level data from the Childhood Leukemia International Consortium (CLIC) and non-CLIC studies.

Material/Methods:

We analyzed data of 3182 incident AML cases and 8377 controls from 17 studies [seven registry-based case-control (RCC) studies and ten questionnaire-based case-control (QCC) studies]. AML risk in association with parental age was calculated using multiple logistic regression, meta-analyses, and pooled-effect estimates. Models were stratified by age at diagnosis (infants <1 year-old vs. children 1-14 years-old) and by study design, using five-year parental age increments and controlling for sex, ethnicity, birthweight, prematurity, multiple gestation, birth order, maternal smoking and education, age at diagnosis (cases aged 1-14 years), and recruitment time period.

Results:

Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) derived from RCC, but not from the QCC, studies showed a higher AML risk for infants of mothers ≥40-year-old (OR = 6.87; 95% CI: 2.12-22.25). There were no associations observed between any other maternal or paternal age group and AML risk for children older than one year.

Conclusions:

An increased risk of infant AML with advanced maternal age was found using data from RCC, but not QCC studies; no parental age-AML associations were observed for older children.


Subject:
[+]
Adolescent
Adult
Article
Birth Weight
Case-Control Studies
Child
Child, Preschool
Childhood Cancer
Epidemiology
Female
Humans
Infant
Infant, Newborn
Infant Acute Myeloid Leukemia
Leukemia, Myeloid, Acute
Logistic Models
Male
Maternal Age
Parents
Paternal Age
Registries
Risk
Risk Factors
Surveys And Questionnaires
Young Adult

Source:
Cancer Epidemiol. 59:158-165
Pubmed ID:
30776582
Pubmed Central ID:
PMC7098424
Document Type:
Journal Article
Funding:
U58 DP000783/DP/NCCDPHP CDC HHS/United States ; R21 CA175959/CA/NCI NIH HHS/United States ; R13 ES024632/ES/NIEHS NIH HHS/United States ; R03 ES021643/ES/NIEHS NIH HHS/United States ; R13 ES021145/ES/NIEHS NIH HHS/United States ; ... More +
U58 DP000783/DP/NCCDPHP CDC HHS/United States ; R21 CA175959/CA/NCI NIH HHS/United States ; R13 ES024632/ES/NIEHS NIH HHS/United States ; R03 ES021643/ES/NIEHS NIH HHS/United States ; R13 ES021145/ES/NIEHS NIH HHS/United States ; P01 ES018172/ES/NIEHS NIH HHS/United States ; R01 CA175737/CA/NCI NIH HHS/United States ; R01 ES009137/ES/NIEHS NIH HHS/United States ; R13 ES022868/ES/NIEHS NIH HHS/United States ; U13 ES026496/ES/NIEHS NIH HHS/United States ; HHSN261201300012I/CA/NCI NIH HHS/United States ; R01 CA155461/CA/NCI NIH HHS/United States ; R03 CA132172/CA/NCI NIH HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:e034ae2bd64c846e1d8e6607aec80c48c792f56d661eaccb8f1e0cdf0c25e7b1
File Type:

Supporting Files

• 	nihms-1562697.nxml	xml
  	NIHMS1562697-supplement-R1_Panagopoulou_Highlights.docx	docx
  	NIHMS1562697-supplement-R1_Supplementary_Tables_1-3_and_Figure.doc	doc

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