Parental age and the risk of childhood acute myeloid leukemia: results from the Childhood Leukemia International Consortium

Details

• Alternative Title:
  Cancer Epidemiol
• Personal Author:
  Panagopoulou, Paraskevi ; Skalkidou, Alkistis ; Marcotte, Erin ; Erdmann, Friederike ; Ma, Xiaomei ; Heck, Julia E ; Auvinen, Anssi ; Mueller, Beth A ; Spector, Logan G ; Roman, Eve ; Metayer, Catherine ; Magnani, Corrado ; Pombo-de-Oliveira, Maria S ; Scheurer, Michael E ; Mora, Ana M ; Dockerty, John D ; Hansen, Johnni ; Kang, Alice Y ; Wang, Rong ; Doody, David R ; Kane, Eleanor ; Schüz, Joachim ; Christodoulakis, Christos ; Ntzani, Evangelia ; Petridou, EleniTh
• Corporate Authors:
  FRECCLE group ; NARECHEM-ST group
• Description:
  Background:
  
  Parental age has been associated with several childhood cancers, albeit the evidence is still inconsistent.
  
  Aim:
  
  To examine the associations of parental age at birth with acute myeloid leukemia (AML) among children aged 0-14 years using individual-level data from the Childhood Leukemia International Consortium (CLIC) and non-CLIC studies.
  
  Material/Methods:
  
  We analyzed data of 3182 incident AML cases and 8377 controls from 17 studies [seven registry-based case-control (RCC) studies and ten questionnaire-based case-control (QCC) studies]. AML risk in association with parental age was calculated using multiple logistic regression, meta-analyses, and pooled-effect estimates. Models were stratified by age at diagnosis (infants <1 year-old vs. children 1-14 years-old) and by study design, using five-year parental age increments and controlling for sex, ethnicity, birthweight, prematurity, multiple gestation, birth order, maternal smoking and education, age at diagnosis (cases aged 1-14 years), and recruitment time period.
  
  Results:
  
  Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) derived from RCC, but not from the QCC, studies showed a higher AML risk for infants of mothers ≥40-year-old (OR = 6.87; 95% CI: 2.12-22.25). There were no associations observed between any other maternal or paternal age group and AML risk for children older than one year.
  
  Conclusions:
  
  An increased risk of infant AML with advanced maternal age was found using data from RCC, but not QCC studies; no parental age-AML associations were observed for older children.
  
  
• Subjects:
  Adolescent Adult Article Birth Weight Case-Control Studies Child Child, Preschool Childhood Cancer Epidemiology Female Humans Infant Infant, Newborn Infant Acute Myeloid Leukemia Leukemia, Myeloid, Acute Logistic Models Male Maternal Age Parents Paternal Age Registries Risk Risk Factors Surveys And Questionnaires Young Adult

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• Source:
  Cancer Epidemiol. 59:158-165
• Pubmed ID:
  30776582
• Pubmed Central ID:
  PMC7098424
• Document Type:
  Journal Article
• Funding:
  U58 DP000783/DP/NCCDPHP CDC HHS/United States ; R21 CA175959/CA/NCI NIH HHS/United States ; R13 ES024632/ES/NIEHS NIH HHS/United States ; R03 ES021643/ES/NIEHS NIH HHS/United States ; R13 ES021145/ES/NIEHS NIH HHS/United States ; P01 ES018172/ES/NIEHS NIH HHS/United States ; R01 CA175737/CA/NCI NIH HHS/United States ; R01 ES009137/ES/NIEHS NIH HHS/United States ; R13 ES022868/ES/NIEHS NIH HHS/United States ; U13 ES026496/ES/NIEHS NIH HHS/United States ; HHSN261201300012I/CA/NCI NIH HHS/United States ; R01 CA155461/CA/NCI NIH HHS/United States ; R03 CA132172/CA/NCI NIH HHS/United States
• Volume:
  59
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:e034ae2bd64c846e1d8e6607aec80c48c792f56d661eaccb8f1e0cdf0c25e7b1
• Download URL:
  https://stacks.cdc.gov/view/cdc/86184/cdc_86184_DS1.pdf
• File Type:
  [PDF - 388.89 KB ]