CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners.
As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.
i
Some ototoxic drugs destroy cochlear support cells before damaging sensory hair cells
-
3 2020
-
-
Source: Neurotox Res. 37(3):743-752
Details:
-
Alternative Title:Neurotox Res
-
Personal Author:
-
Description:A wide variety of ototoxic drugs are capable of damaging the sensory hair cells in the mammalian cochlea resulting in permanent hearing loss. However, the toxic properties of these drugs suggest that some could potentially damage cochlear support cells as well. To test the hypothesis, we treated postnatal day three rat cochlear cultures with toxic doses of gentamicin, cisplatin, mefloquine, and cadmium. Gentamicin primarily destroyed the hair cells and disrupted the intercellular connection with the surrounding support cells. Gentamicin-induced hair cell death was initiated through the caspase-9 intrinsic apoptotic pathway followed by activation of downstream executioner caspase-3. In contrast, cisplatin, mefloquine, and cadmium initially damaged the support cells and only later damaged the hair cells. Support cell death was initiated through the caspase-8 extrinsic apoptotic pathway followed later by downstream activation of caspase-3. Cisplatin, mefloquine, and cadmium significantly reduced the expression of actin and laminin, in the extracellular matrix, leading to significant disarray of the sensory epithelium.
-
Subjects:
-
Keywords:
-
Source:
-
Pubmed ID:31997155
-
Pubmed Central ID:PMC7065960
-
Document Type:
-
Funding:
-
Volume:37
-
Issue:3
-
Collection(s):
-
Main Document Checksum:
-
Download URL:
-
File Type: