Details:

Alternative Title:
Neurotox Res
Publisher's site:
http://dx.doi.org/10.1007/s12640-015-9531-2
Personal Author:
Yu, Jintao ; Ding, Dalian ; Sun, Hong ; Salvi, Richard ; Roth, Jerome A.
Yu, Jintao ; Ding, Dalian ; Sun, Hong ; Salvi, Richard ; Roth, Jerome A. Less -
Description:
Trimethyltin (TMT), which has a variety of applications in industry and agricultural, is a neurotoxin that is known to affect the auditory system as well as central nervous system of humans and experimental animals. However, the mechanisms underlying TMT-induced auditory dysfunction are poorly understood. To gain insights into the neurotoxic effect of TMT on the peripheral auditory system, we treated cochlear organotypic cultures with concentrations of TMT ranging from 5 to 100 μM for 24 h. Interestingly, TMT preferentially damaged auditory nerve fibers and spiral ganglion neurons in a dose-dependent manner, but had no noticeable effects on the sensory hair cells at the doses employed. TMT-induced damage to auditory neurons was associated with significant soma shrinkage, nuclear condensation, and activation of caspase-3, biomarkers indicative of apoptotic cell death. Our findings show that TMT is exclusively neurotoxicity in rat cochlear organotypic culture and that TMT-induced auditory neuron death occurs through a caspase-mediated apoptotic pathway.
Subjects:
[+]
Animals Apoptosis Article Caspase-3 Caspase 3 Cochlea Cochlear Nerve Hair Cells, Auditory Neurotoxicity Organ Culture Techniques Rats Rats, Sprague-Dawley Spiral Ganglion Neurons Trimethyltin Trimethyltin Compounds
Source:
Neurotox Res. 28(1):43-54.
Pubmed ID:
25957118
Pubmed Central ID:
PMC4446228
Document Type:
Journal Article
Funding:
R01 OH010235/OH/NIOSH CDC HHS/United States ; R01OH010235/OH/NIOSH CDC HHS/United States
R01 OH010235/OH/NIOSH CDC HHS/United States ; R01OH010235/OH/NIOSH CDC HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:fd9424365155d1f98e485c91c75a5f3b1657f7d320343c8b38c38c0ad5cbeec1
Download URL:
https://stacks.cdc.gov/view/cdc/31320/cdc_31320_DS1.pdf
File Type:

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