Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Huang, Chuan-Chin ; Chu, Alexander L. ; Becerra, Mercedes C. ; Galea, Jerome T. ; Calderón, Roger ; ... More +
Huang, Chuan-Chin ; Chu, Alexander L. ; Becerra, Mercedes C. ; Galea, Jerome T. ; Calderón, Roger ; Contreras, Carmen ; Yataco, Rosa ; Zhang, Zibiao ; Lecca, Leonid ; Murray, Megan B. Less -
Description:
Few studies have prospectively compared the relative transmissibility and propensity to cause disease of Mycobacterium tuberculosis Beijing strains with other human-adapted strains of the M. tuberculosis complex. We assessed the effect of Beijing strains on the risk for M. tuberculosis infection and disease progression in 9,151 household contacts of 2,223 culture-positive pulmonary tuberculosis (TB) patients in Lima, Peru. Child contacts exposed to Beijing strains were more likely than child contacts exposed to non-Beijing strains to be infected at baseline, by 12 months of follow-up, and during follow-up. We noted an increased but nonsignificant tendency for child contacts to develop TB. Beijing strains were not associated with TB in adult contacts. These findings suggest that Beijing strains are more transmissible in children than are non-Beijing strains.
Subject:
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Bacteria
BCG Vaccine
Infection Transmission
Latent tuberculosis infection
Mycobacterium Tuberculosis
Mycobacterium Tuberculosis Beijing Lineage And Risk For Tuberculosis In Child Household Contacts, Peru
Research
Tuberculosis
Tuberculosis And Other Mycobacteria

Source:
Emerg Infect Dis. 26(3):568-578
Pubmed ID:
32091363
Pubmed Central ID:
PMC7045848
Document Type:
Journal Article
Place as Subject:
Peru
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:ef63ac9ac9e0d5c4ab8f4720f0bb192c078ea62c338e19796e5696cee3ac389c
File Type:

Supporting Files

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