Mycobacterium tuberculosis Beijing Lineage and Risk for Tuberculosis in Child Household Contacts, Peru

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Huang, Chuan-Chin ; Chu, Alexander L. ; Becerra, Mercedes C. ; Galea, Jerome T. ; Calderón, Roger ; Contreras, Carmen ; Yataco, Rosa ; Zhang, Zibiao ; Lecca, Leonid ; Murray, Megan B.
• Description:
  Few studies have prospectively compared the relative transmissibility and propensity to cause disease of Mycobacterium tuberculosis Beijing strains with other human-adapted strains of the M. tuberculosis complex. We assessed the effect of Beijing strains on the risk for M. tuberculosis infection and disease progression in 9,151 household contacts of 2,223 culture-positive pulmonary tuberculosis (TB) patients in Lima, Peru. Child contacts exposed to Beijing strains were more likely than child contacts exposed to non-Beijing strains to be infected at baseline, by 12 months of follow-up, and during follow-up. We noted an increased but nonsignificant tendency for child contacts to develop TB. Beijing strains were not associated with TB in adult contacts. These findings suggest that Beijing strains are more transmissible in children than are non-Beijing strains.
• Subjects:
  Adolescent Adult Age Factors Child Child, Preschool Family Characteristics Female Humans Infant Infant, Newborn Male Middle Aged Mycobacterium Tuberculosis Prospective Studies Risk Factors Survival Analysis Tuberculosis, Pulmonary Young Adult

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• Source:
  Emerg Infect Dis. 26(3):568-578
• Pubmed ID:
  32091363
• Pubmed Central ID:
  PMC7045848
• Document Type:
  Journal Article
• Place as Subject:
  Peru
• Volume:
  26
• Issue:
  3
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:ef63ac9ac9e0d5c4ab8f4720f0bb192c078ea62c338e19796e5696cee3ac389c
• Download URL:
  https://stacks.cdc.gov/view/cdc/85688/cdc_85688_DS1.pdf
• File Type:
  [PDF - 976.65 KB ]