Pregnancy Outcomes among Women Receiving rVSVΔ-ZEBOV-GP Ebola Vaccine during the Sierra Leone Trial to Introduce a Vaccine against Ebola

Legardy-Williams, Jennifer K.; Carter, Rosalind J.; Goldstein, Susan T.; Jarrett, Olamide D.; Szefer, Elena; Fombah, Augustin E.; Tinker, Sarah C.; Samai, Mohamed; Mahon, Barbara E.

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Pregnancy Outcomes among Women Receiving rVSVΔ-ZEBOV-GP Ebola Vaccine during the Sierra Leone Trial to Introduce a Vaccine against Ebola

Supporting Files Public Domain

March 17 2020
By Legardy-Williams, Jennifer K. ; Carter, Rosalind J. ; Goldstein, Susan T. ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Legardy-Williams, Jennifer K. ; Carter, Rosalind J. ; Goldstein, Susan T. ; Jarrett, Olamide D. ; Szefer, Elena ; Fombah, Augustin E. ; Tinker, Sarah C. ; Samai, Mohamed ; Mahon, Barbara E.
Description:

Little information exists regarding Ebola vaccine rVSVΔG-ZEBOV-GP and pregnancy. The Sierra Leone Trial to Introduce a Vaccine against Ebola (STRIVE) randomized participants without blinding to immediate or deferred (18-24 weeks postenrollment) vaccination. Pregnancy was an exclusion criterion, but 84 women were inadvertently vaccinated in early pregnancy or became pregnant <60 days after vaccination or enrollment. Among immediate vaccinated women, 45% (14/31) reported pregnancy loss, compared with 33% (11/33) of unvaccinated women with contemporaneous pregnancies (relative risk 1.35, 95% CI 0.73-2.52). Pregnancy loss was similar among women with higher risk for vaccine viremia (conception before or <14 days after vaccination) (44% [4/9]) and women with lower risk (conception >15 days after vaccination) (45% [10/22]). No congenital anomalies were detected among 44 live-born infants examined. These data highlight the need for Ebola vaccination decisions to balance the possible risk for an adverse pregnancy outcome with the risk for Ebola exposure.
Subjects:

Adult Double-Blind Method Ebola Vaccines Female Hemorrhagic Fever, Ebola Humans Pregnancy Pregnancy Complications, Infectious Pregnancy Outcome Prenatal Care Vaccination Young Adult
Source:

Emerg Infect Dis. 26(3):541-548
Pubmed ID:

32017677
Pubmed Central ID:

PMC7045819
Document Type:

Journal Article
Place as Subject:

Sierra Leone
Volume:

26
Issue:

3
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:7ef50e5c60f7a360760157d764f9b3cec47ac6d080337bb32d6b964a63d7bfcd
Download URL:

https://stacks.cdc.gov/view/cdc/85681/cdc_85681_DS1.pdf
File Type:

[PDF - 1.30 MB ]

File Language:

English

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