Pregnancy Outcomes among Women Receiving rVSVΔ-ZEBOV-GP Ebola Vaccine during the Sierra Leone Trial to Introduce a Vaccine against Ebola

Legardy-Williams, Jennifer K.; Carter, Rosalind J.; Goldstein, Susan T.; Jarrett, Olamide D.; Szefer, Elena; Fombah, Augustin E.; Tinker, Sarah C.; Samai, Mohamed; Mahon, Barbara E.

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Pregnancy Outcomes among Women Receiving rVSVΔ-ZEBOV-GP Ebola Vaccine during the Sierra Leone Trial to Introduce a Vaccine against Ebola

Published Date:

March 17 2020

Source:

Emerg Infect Dis. 26(3):541-548

Language:

English

[PDF-1.30 MB]

Details:

Alternative Title:

Emerg Infect Dis

Personal Author:

Legardy-Williams, Jennifer K. ; Carter, Rosalind J. ; Goldstein, Susan T. ; Jarrett, Olamide D. ; Szefer, Elena ; ... More ▼

Description:

Little information exists regarding Ebola vaccine rVSVΔG-ZEBOV-GP and pregnancy. The Sierra Leone Trial to Introduce a Vaccine against Ebola (STRIVE) randomized participants without blinding to immediate or deferred (18-24 weeks postenrollment) vaccination. Pregnancy was an exclusion criterion, but 84 women were inadvertently vaccinated in early pregnancy or became pregnant <60 days after vaccination or enrollment. Among immediate vaccinated women, 45% (14/31) reported pregnancy loss, compared with 33% (11/33) of unvaccinated women with contemporaneous pregnancies (relative risk 1.35, 95% CI 0.73-2.52). Pregnancy loss was similar among women with higher risk for vaccine viremia (conception before or <14 days after vaccination) (44% [4/9]) and women with lower risk (conception >15 days after vaccination) (45% [10/22]). No congenital anomalies were detected among 44 live-born infants examined. These data highlight the need for Ebola vaccination decisions to balance the possible risk for an adverse pregnancy outcome with the risk for Ebola exposure.

Subject:

[+]

Pubmed ID:

32017677

Pubmed Central ID:

PMC7045819

Document Type:

Journal Article

Place as Subject:

Sierra Leone

Collection(s):

Emerging Infectious Diseases

Main Document Checksum:

[+]

Supporting Files:

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