Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Legardy-Williams, Jennifer K. ; Carter, Rosalind J. ; Goldstein, Susan T. ; Jarrett, Olamide D. ; Szefer, Elena ; ... More +
Legardy-Williams, Jennifer K. ; Carter, Rosalind J. ; Goldstein, Susan T. ; Jarrett, Olamide D. ; Szefer, Elena ; Fombah, Augustin E. ; Tinker, Sarah C. ; Samai, Mohamed ; Mahon, Barbara E. ; Less -
Description:
Little information exists regarding Ebola vaccine rVSVΔG-ZEBOV-GP and pregnancy. The Sierra Leone Trial to Introduce a Vaccine against Ebola (STRIVE) randomized participants without blinding to immediate or deferred (18-24 weeks postenrollment) vaccination. Pregnancy was an exclusion criterion, but 84 women were inadvertently vaccinated in early pregnancy or became pregnant <60 days after vaccination or enrollment. Among immediate vaccinated women, 45% (14/31) reported pregnancy loss, compared with 33% (11/33) of unvaccinated women with contemporaneous pregnancies (relative risk 1.35, 95% CI 0.73-2.52). Pregnancy loss was similar among women with higher risk for vaccine viremia (conception before or <14 days after vaccination) (44% [4/9]) and women with lower risk (conception >15 days after vaccination) (45% [10/22]). No congenital anomalies were detected among 44 live-born infants examined. These data highlight the need for Ebola vaccination decisions to balance the possible risk for an adverse pregnancy outcome with the risk for Ebola exposure.
Subject:
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Ebola
Ebola Vaccine
Ebola Virus
Ebola Virus Disease
Pregnancy
Pregnancy Outcomes Among Women Receiving RVSVΔ-ZEBOV-GP Ebola Vaccine During The Sierra Leone Trial To Introduce A Vaccine Against Ebola
Research
RVSVΔ-ZEBOV-GP
STRIVE
Vaccine-preventable Diseases
Vaccine Safety
Viruses

Source:
Emerg Infect Dis. 26(3):541-548 ;
Pubmed ID:
32017677
Pubmed Central ID:
PMC7045819
Document Type:
Journal Article ;
Place as Subject:
Sierra Leone ;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:7ef50e5c60f7a360760157d764f9b3cec47ac6d080337bb32d6b964a63d7bfcd
File Type:

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