Stable and Local Reservoirs of Mycobacterium ulcerans Inferred from the Nonrandom Distribution of Bacterial Genotypes, Benin

Coudereau, Clément; Besnard, Alban; Robbe-Saule, Marie; Bris, Céline; Kempf, Marie; Johnson, Roch Christian; Brou, Télésphore Yao; Gnimavo, Ronald; Eyangoh, Sara; Khater, Fida; Marion, Estelle

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Stable and Local Reservoirs of Mycobacterium ulcerans Inferred from the Nonrandom Distribution of Bacterial Genotypes, Benin

Mar 2020
By Coudereau, Clément ; Besnard, Alban ; Robbe-Saule, Marie ; ...
Source: Emerg Infect Dis. 26(3):491-503

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English

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Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

Coudereau, Clément ; Besnard, Alban ; Robbe-Saule, Marie ; Bris, Céline ; Kempf, Marie ; ... More +

Coudereau, Clément ; Besnard, Alban ; Robbe-Saule, Marie ; Bris, Céline ; Kempf, Marie ; Johnson, Roch Christian ; Brou, Télésphore Yao ; Gnimavo, Ronald ; Eyangoh, Sara ; Khater, Fida ; Marion, Estelle Less -
Description:

Mycobacterium ulcerans is the causative agent of Buruli ulcer, a neglected tropical disease found in rural areas of West and Central Africa. Despite the ongoing efforts to tackle Buruli ulcer epidemics, the environmental reservoir of its pathogen remains elusive, underscoring the need for new approaches to improving disease prevention and management. In our study, we implemented a local-scale spatial clustering model and deciphered the genetic diversity of the bacteria in a small area of Benin where Buruli ulcer is endemic. Using 179 strain samples from West Africa, we conducted a phylogeographic analysis combining whole-genome sequencing with spatial scan statistics. The 8 distinct genotypes we identified were by no means randomly spread over the studied area. Instead, they were divided into 3 different geographic clusters, associated with landscape characteristics. Our results highlight the ability of M. ulcerans to evolve independently and differentially depending on location in a specific ecologic reservoir.
Subjects:

[+]

Bacteria Buruli Ulcer Genetic Diversity Genomic Analysis Genotyping Geospatial Model Mutational Profiling Mycobacterium Ulcerans Research Stable And Local Reservoirs Of Mycobacterium Ulcerans Inferred From The Nonrandom Distribution Of Bacterial Genotypes, Benin Tuberculosis And Other Mycobacteria
Source:

Emerg Infect Dis. 26(3):491-503
Pubmed ID:

32091371
Pubmed Central ID:

PMC7045821
Document Type:

Journal Article
Place as Subject:

Benin ; Nigeria

Benin ; Nigeria Less -
Location:

Africa
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

[+]

urn:sha256:b23b011417edccada759dc98be9faa51d0f104448d90dc59c12a868c0777c4bc
Download URL:

https://stacks.cdc.gov/view/cdc/85669/cdc_85669_DS1.pdf
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