Clinical Characteristics of Disseminated Strongyloidiasis, Japan, 1975–2017

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Mukaigawara, Mitsuru ; Narita, Masashi ; Shiiki, Soichi ; Takayama, Yoshihiro ; Takakura, Shunichi ; Kishaba, Tomokazu
• Description:
  Clinical characteristics of disseminated strongyloidiasis, the severest form of strongyloidiasis, are not well described. We conducted a retrospective, consecutive chart review of patients with disseminated strongyloidiasis admitted to Okinawa Chubu Hospital in Okinawa, Japan, during January 1975-December 2017. The 70 patients were classified into 3 clinical phenotypes: dissemination (32 patients [45.7%]), occult dissemination with meningitis caused by enteric organisms (12 patients [17.1%]), and occult dissemination with culture-negative suppurative meningitis (26 patients [37.1%]). Associated mortality rates were 56.3%, 16.7%, and 11.5%, respectively, and sepsis occurred in 40.6%, 58.3%, and 11.5% of cases, respectively. Common symptoms included fever (52.9% of patients), headache (32.9%), and altered mental status (24.3%). Patients were treated with thiabendazole (before 2003) or ivermectin (after 2003). Our findings show that disseminated strongyloidiasis has clinical phenotypes in terms of severity and that identification of occult dissemination, a mild form with prominent neurologic manifestations, is lifesaving.
• Subjects:
  Clinical Characteristics Of Disseminated Strongyloidiasis, Japan, 1975–2017 Dissemination HTLV-1 Human T-cell Lymphotrophic Virus Type 1 Meningitis Nematodes Parasites Roundworms Strongyloides Stercoralis Strongyloidiasis Synopsis

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• Source:
  Emerg Infect Dis. 26(3):401-408
• Pubmed ID:
  32091375
• Pubmed Central ID:
  PMC7045830
• Document Type:
  Journal Article
• Place as Subject:
  Japan
• Location:
  Asia
• Volume:
  26
• Issue:
  3
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:e2e8fd0892f8daddce788814f53d78567f2c8b8c34eebda700ed319bcb0b7758
• Download URL:
  https://stacks.cdc.gov/view/cdc/85668/cdc_85668_DS1.pdf
• File Type:
  [PDF - 1.51 MB ]