Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Rongkard, Patpong ; Kronsteiner, Barbara ; Hantrakun, Viriya ; Jenjaroen, Kemajittra ; Sumonwiriya, Manutsanun ; ... More +
Rongkard, Patpong ; Kronsteiner, Barbara ; Hantrakun, Viriya ; Jenjaroen, Kemajittra ; Sumonwiriya, Manutsanun ; Chaichana, Panjaporn ; Chumseng, Suchintana ; Chantratita, Narisara ; Wuthiekanun, Vanaporn ; Fletcher, Helen A. ; Teparrukkul, Prapit ; Limmathurotsakul, Direk ; Day, Nicholas P.J. ; Dunachie, Susanna J. Less -
Description:
Melioidosis is a neglected tropical disease with an estimated annual mortality rate of 89,000 in 45 countries across tropical regions. The causative agent is Burkholderia pseudomallei, a gram-negative soil-dwelling bacterium. In Thailand, B. pseudomallei can be found across multiple regions, along with the low-virulence B. thailandensis and the recently discovered B. thailandensis variant (BTCV), which expresses B. pseudomallei-like capsular polysaccharide. Comprehensive studies of human immune responses to B. thailandensis variants and cross-reactivity to B. pseudomallei are not complete. We evaluated human immune responses to B. pseudomallei, B. thailandensis, and BTCV in melioidosis patients and healthy persons in B. pseudomallei-endemic areas using a range of humoral and cellular immune assays. We found immune cross-reactivity to be strong for both humoral and cellular immunity among B. pseudomallei, B. thailandensis, and BTCV. Our findings suggest that environmental exposure to low-virulence strains may build cellular immunity to B. pseudomallei.
Subjects:
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Bacteria Burkholderia Pseudomallei Burkholderia Thailandensis Burkholderia Thailandensis CPS Variant Capsular Polysaccharide ELISA Human Immune Responses To Melioidosis And Cross-Reactivity To Low-Virulence Burkholderia Species, Thailand Immune Cross-reactivity Indirect Hemagglutination Assay Interferon-γ ELISpot Melioidosis Research Whole Blood Stimulation Assay
Source:
Emerg Infect Dis. 26(3):463-471
Pubmed ID:
32091359
Pubmed Central ID:
PMC7045851
Document Type:
Journal Article
Place as Subject:
Thailand
Location:
Asia
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:466c7825d660c6b817e52d90451335dd3163e713f670a1c8ee7dd506d6ba5c3a
Download URL:
https://stacks.cdc.gov/view/cdc/85662/cdc_85662_DS1.pdf
File Type:

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