Human Immune Responses to Melioidosis and Cross-Reactivity to Low-Virulence Burkholderia Species, Thailand1

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Rongkard, Patpong ; Kronsteiner, Barbara ; Hantrakun, Viriya ; Jenjaroen, Kemajittra ; Sumonwiriya, Manutsanun ; Chaichana, Panjaporn ; Chumseng, Suchintana ; Chantratita, Narisara ; Wuthiekanun, Vanaporn ; Fletcher, Helen A. ; Teparrukkul, Prapit ; Limmathurotsakul, Direk ; Day, Nicholas P.J. ; Dunachie, Susanna J.
• Description:
  Melioidosis is a neglected tropical disease with an estimated annual mortality rate of 89,000 in 45 countries across tropical regions. The causative agent is Burkholderia pseudomallei, a gram-negative soil-dwelling bacterium. In Thailand, B. pseudomallei can be found across multiple regions, along with the low-virulence B. thailandensis and the recently discovered B. thailandensis variant (BTCV), which expresses B. pseudomallei-like capsular polysaccharide. Comprehensive studies of human immune responses to B. thailandensis variants and cross-reactivity to B. pseudomallei are not complete. We evaluated human immune responses to B. pseudomallei, B. thailandensis, and BTCV in melioidosis patients and healthy persons in B. pseudomallei-endemic areas using a range of humoral and cellular immune assays. We found immune cross-reactivity to be strong for both humoral and cellular immunity among B. pseudomallei, B. thailandensis, and BTCV. Our findings suggest that environmental exposure to low-virulence strains may build cellular immunity to B. pseudomallei.
• Subjects:
  Bacteria Burkholderia Pseudomallei Burkholderia Thailandensis Burkholderia Thailandensis CPS Variant Capsular Polysaccharide ELISA Human Immune Responses To Melioidosis And Cross-Reactivity To Low-Virulence Burkholderia Species, Thailand Immune Cross-reactivity Indirect Hemagglutination Assay Interferon-γ ELISpot Melioidosis Research Whole Blood Stimulation Assay

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• Source:
  Emerg Infect Dis. 26(3):463-471
• Pubmed ID:
  32091359
• Pubmed Central ID:
  PMC7045851
• Document Type:
  Journal Article
• Place as Subject:
  Thailand
• Location:
  Asia
• Volume:
  26
• Issue:
  3
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:466c7825d660c6b817e52d90451335dd3163e713f670a1c8ee7dd506d6ba5c3a
• Download URL:
  https://stacks.cdc.gov/view/cdc/85662/cdc_85662_DS1.pdf
• File Type:
  [PDF - 1.63 MB ]