Measles immunity among pregnant women aged 15–44 years in Namibia, 2008 and 2010☆

Cardemil, Cristina V.; Jonas, Anna; Beukes, Anita; Anderson, Raydel; Rota, Paul A.; Bankamp, Bettina; Gary, Howard E.; Sawadogo, Souleymane; Patel, Sadhna V.; Zeko, Sikota; Muroua, Clementine; Gaeb, Esegiel; Wannemuehler, Kathleen; Gerber, Sue; Goodson, James L.

doi:10.1016/j.ijid.2016.05.020

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Measles immunity among pregnant women aged 15–44 years in Namibia, 2008 and 2010☆

May 24 2016
By Cardemil, Cristina V. ; Jonas, Anna ; Beukes, Anita ; ...
http://dx.doi.org/10.1016/j.ijid.2016.05.020
Source: Int J Infect Dis. 49:189-195

English

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Details:

Alternative Title:

Int J Infect Dis
Personal Author:

Cardemil, Cristina V. ; Jonas, Anna ; Beukes, Anita ; Anderson, Raydel ; Rota, Paul A. ; ... More +

Cardemil, Cristina V. ; Jonas, Anna ; Beukes, Anita ; Anderson, Raydel ; Rota, Paul A. ; Bankamp, Bettina ; Gary, Howard E. ; Sawadogo, Souleymane ; Patel, Sadhna V. ; Zeko, Sikota ; Muroua, Clementine ; Gaeb, Esegiel ; Wannemuehler, Kathleen ; Gerber, Sue ; Goodson, James L. Less -
Description:

Background:

Namibia experienced a large measles outbreak starting in 2009, with 38% of reported cases in adults, including women of reproductive age. Population immunity was assessed among pregnant women to determine whether immunization activities were needed in adults to achieve measles elimination in Namibia.

Methods:

A total of 1708 and 2040 specimens sampled from Namibian pregnant women aged 15–44 years who were included in the 2008 and 2010 National HIV Sentinel Survey, respectively, were tested for measles immunoglobulin G antibody. The proportion of women seropositive overall and by 5-year age strata was determined, and factors associated with seropositivity were analyzed by logistic regression, including age, facility type, gravidity, HIV status, and urban/rural setting. Seropositivity in 2008 versus 2010 was compared.

Results:

In both analysis years, measles seropositivity was lower in 15–19-year-olds (77%) and 20–24-year-olds (85–87%) and higher in 25–44-year-olds (90–94%) (2008, p < 0.001; 2010, p < 0.001). Overall measles seropositivity did not differ between 2008 (87%) and 2010 (87%) (p = 0.7). HIV status did not affect seropositivity.

Conclusions:

Late in a large measles outbreak, 13% of pregnant women in Namibia, and almost one in four 15–19-year-old pregnant women, remained susceptible to measles. In Namibia, immunization campaigns with measles-containing vaccine should be considered for adults.
Subjects:

[+]

Adolescent Adult Antibodies, Viral Article Female Humans Immunization Immunoglobulin G Male Measles Measles Vaccine Namibia Population Immunity Pregnancy Pregnant Women Seroprevalence Young Adult
Source:

Int J Infect Dis. 49:189-195
Pubmed ID:

27235084
Pubmed Central ID:

PMC6996213
Document Type:

Journal Article
Funding:

CC999999/ImCDC/Intramural CDC HHS/United States
Volume:

49
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:175d54ae9d25c020a438f7d069e1b0136b543165acee0a45af9ac58f76cdb3dd
Download URL:

https://stacks.cdc.gov/view/cdc/84927/cdc_84927_DS1.pdf
File Type:

[PDF-380.23 KB]

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