Poliovirus Immunity Among Pregnant Females Aged 15–44 Years, Namibia, 2010

Details

• Alternative Title:
  J Infect Dis
• Personal Author:
  Cardemil, Cristina V. ; Jonas, Anna ; Gerber, Sue ; Weldon, William C. ; Oberste, M. Steven ; Beukes, Anita ; Sawadogo, Souleymane ; Patel, Sadhna V. ; Zeko, Sikota ; Muroua, Clementine ; Gaeb, Esegiel ; Wannemuehler, Kathleen ; Goodson, James L.
• Description:
  Background.
  
  Poliovirus (PV) antibody seroprevalence studies assess population immunity, verify an immunization program’s performance and vaccine efficacy, and guide polio eradication strategy. Namibia experienced a polio outbreak among adults in 2006, yet population seroimmunity was unknown.
  
  Methods.
  
  We tested 2061 specimens from Namibian pregnant females aged 15–44 years for neutralizing antibody to PV types 1–3 (PV1–3); all females were sampled during the 2010 National HIV Sentinel Survey. We determined the proportion of females seropositive for PV antibody by 5-year age strata, and analyzed factors associated with seropositivity, including age, gravidity, human immunodeficiency virus (HIV) infection status, residence, and antiretroviral treatment, by log-binomial regression.
  
  Results.
  
  The seroprevalence was 94.6% for PV1, 97.0% for PV2, and 85.1% for PV3. HIV-positive females had significantly lower seroprevalence than HIV-negative females for PV1 (91.8% vs 95.3%; P < .01) and PV3 (80.0% vs 86.1%; P < .01) but not for PV2 (96.4% vs 97.1%; P = .3). The prevalence ratio of seropositivity for HIV-positive females versus HIV-negative females was 0.95 (95% confidence interval [CI], .92–.98) for PV1, 0.99 (95% CI, .97–1.01) for PV2, and 0.92 (95% CI, .87–.96) for PV3.
  
  Conclusions.
  
  Despite relatively high PV seroprevalence, Namibia might remain at risk for a PV outbreak, particularly in lower-seroprevalence populations, such as HIV-positive females. Namibia should continue to maintain high routine polio vaccination coverage.
  
  
• Subjects:
  Adolescent Adult Antibodies, Neutralizing Antibodies, Viral Disease Outbreaks Female Humans Namibia Poliomyelitis Poliovirus Poliovirus Vaccines Pregnancy Seroepidemiologic Studies Vaccination Young Adult

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• Keywords:
  Adults HIV Neutralizing Antibody OPV Polio Population Immunity Pregnant Women Seroprevalence
• Source:
  J Infect Dis. 210(Suppl 1):S136-S142
• Pubmed ID:
  25316828
• Pubmed Central ID:
  PMC6546099
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHSUnited States/
• Volume:
  210
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:b8f670e9c2b32e5c2dd6efe23332c9b8673793815c49347299a148b1b20cb58f356d09803c63db749c319551b2809b5def588a4dbf2c15c0a0e6d5556fe6d980
• Download URL:
  https://stacks.cdc.gov/view/cdc/79093/cdc_79093_DS1.pdf
• File Type:
  [PDF - 79.04 KB ]