Mycoplasma pneumoniae Among Children Hospitalized With Community-acquired Pneumonia

Details

• Journal Article:
  Clin Infect Dis
• Personal Author:
  Kutty, Preeta K. ; Jain, Seema ; Taylor, Thomas H. ; Bramley, Anna M. ; Diaz, Maureen H. ; Ampofo, Krow ; Arnold, Sandra R. ; Williams, Derek J. ; Edwards, Kathryn M. ; McCullers, Jonathan A. ; Pavia, Andrew T. ; Winchell, Jonas M. ; Schrag, Stephanie J. ; Hicks, Lauri A.
  More +
• Description:
  Background. ; The epidemiology of Mycoplasma pneumoniae (Mp) among US children (<18 years) hospitalized with community-acquired pneumonia (CAP) is poorly understood. ; Methods. ; In the Etiology of Pneumonia in the Community study, we prospectively enrolled 2254 children hospitalized with radiographically confirmed pneumonia from January 2010-June 2012 and tested nasopharyngeal/oropharyngeal swabs for Mp using real-time polymerase chain reaction (PCR). Clinical and epidemiological features of Mp PCR–positive and –negative children were compared using logistic regression. Macrolide susceptibility was assessed by genotyping isolates. ; Results. ; One hundred and eighty two (8%) children were Mp PCR-positive (median age, 7 years); 12% required intensive care and 26% had pleural effusion. No in-hospital deaths occurred. Macrolide resistance was found in 4% (6/169) isolates. Of 178 (98%) Mp PCR–positive children tested for copathogens, 50 (28%) had ≥1 copathogen detected. Variables significantly associated with higher odds of Mp detection included age (10–17 years: adjusted odds ratio aOR, 10.7 95% confidence interval {CI}, 5.4–21.1 and 5–9 years: aOR, 6.4 95% CI, 3.4–12.1 vs 2–4 years), outpatient antibiotics ≤5 days preadmission (aOR, 2.3 95% CI, 1.5–3.5), and copathogen detection (aOR, 2.1 95% CI, 1.3–3.3). Clinical characteristics were non-specific. ; Conclusions. ; Usually considered as a mild respiratory infection, Mp was the most commonly detected bacteria among children aged ≥5 years hospitalized with CAP, one-quarter of whom had codetections. Although associated with clinically nonspecific symptoms, there was a need for intensive care in some cases. Mycoplasma pneumoniae should be included in the differential diagnosis for school-aged children hospitalized with CAP.
• Subjects:
  • Adolescent
  • Child
  • Child, Preschool
  • Community-Acquired Infections
  • Female
  • Hospitalization
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  More +
• Keywords:
  • community
  • pneumonia
  • mycoplasma
  • bacterial disease
  • children
  • Chlorination
  • Household water treatment
  • Safe water storage
• Source:
  Clin Infect Dis. 68(1):5-12
• DOI:
  http://dx.doi.org/10.1093/cid/ciy419
• Pubmed ID:
  29788037
• Pubmed Central ID:
  PMC6552676
• Document Type:
  Text ; Journal Article
• Funding:
  CC999999/Intramural CDC HHSUnited States/
• Genre:
  Journal Article
• Volume:
  68
• Issue:
  1
• Download URL:
  https://stacks.cdc.gov/view/cdc/84911/cdc_84911_DS1.pdf
• File Type:
  [PDF - 393.85 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:02bcc8669a38624bf2ba55f66895e8e0e6b0ae33b9b5bb1d7b3c4c7e6387b2e1ba4ec38a8ba9a6d8948358ee8d831411804422bbac1eaa21c7c8774a8276869f