Details:

Alternative Title:
Euro Surveill
Personal Author:
Gubareva, Larisa V ; Fallows, Eric ; Mishin, Vasiliy P ; Hodges, Erin ; Brooks, Abdullah ; ... More +
Gubareva, Larisa V ; Fallows, Eric ; Mishin, Vasiliy P ; Hodges, Erin ; Brooks, Abdullah ; Barnes, John ; Fry, Alicia M ; Kramp, William ; Shively, Roxanne ; Wentworth, David E ; Weidemaier, Kristin ; Jacobson, Ross ; Less -
Description:
A new rapid assay for detecting oseltamivir resistance in influenza virus, iART, was used to test 149 clinical specimens. Results were obtained for 132, with iART indicating 41 as 'resistant'. For these, sequence analysis found known and suspected markers of oseltamivir resistance, while no such markers were detected for the remaining 91 samples. Viruses isolated from the 41 specimens showed reduced or highly reduced inhibition by neuraminidase inhibition assay. iART may facilitate broader antiviral resistance testing.
Subject:
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Air-borne Infections
Antiviral Agents
Drug Resistance, Viral
Humans
Influenza, Human
Influenza A Virus, H1N1 Subtype
Influenza Virus
Microbial Sensitivity Tests
Neuraminidase
Oseltamivir
Rapid Communication
Surveillance
Viral Infections

Source:
Euro Surveill. 2017 ; 22(18);
Pubmed ID:
28494845
Pubmed Central ID:
PMC5434880
Document Type:
Journal Article ;
Collection(s):
CDC Public Access
Main Document Checksum:
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urn:sha256:ed75cbfda24cc1ed7222f649e1e3eefda7f345e73b29f011ad7aba79787e1161
File Type:

Supporting Files

• 	eurosurv-22-30529-f1.gif	gif
  	eurosurv-22-30529-f1.jpg	jpeg
  	eurosurv-22-30529.nxml	xml

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