Monitoring influenza virus susceptibility to oseltamivir using a new rapid assay, iART

Details

• Alternative Title:
  Euro Surveill
• Personal Author:
  Gubareva, Larisa V ; Fallows, Eric ; Mishin, Vasiliy P ; Hodges, Erin ; Brooks, Abdullah ; Barnes, John ; Fry, Alicia M ; Kramp, William ; Shively, Roxanne ; Wentworth, David E ; Weidemaier, Kristin ; Jacobson, Ross
• Description:
  A new rapid assay for detecting oseltamivir resistance in influenza virus, iART, was used to test 149 clinical specimens. Results were obtained for 132, with iART indicating 41 as 'resistant'. For these, sequence analysis found known and suspected markers of oseltamivir resistance, while no such markers were detected for the remaining 91 samples. Viruses isolated from the 41 specimens showed reduced or highly reduced inhibition by neuraminidase inhibition assay. iART may facilitate broader antiviral resistance testing.
• Subjects:
  Air-borne Infections Antiviral Agents Drug Resistance, Viral Humans Influenza, Human Influenza A Virus, H1N1 Subtype Influenza Virus Microbial Sensitivity Tests Neuraminidase Oseltamivir Rapid Communication Surveillance Viral Infections

  More +
• Source:
  Euro Surveill. 2017; 22(18)
• Pubmed ID:
  28494845
• Pubmed Central ID:
  PMC5434880
• Document Type:
  Journal Article
• Volume:
  22
• Issue:
  18
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:ed75cbfda24cc1ed7222f649e1e3eefda7f345e73b29f011ad7aba79787e1161
• Download URL:
  https://stacks.cdc.gov/view/cdc/84848/cdc_84848_DS1.pdf
• File Type:
  [PDF - 427.60 KB ]