Characteristics of Patients with Acute Flaccid Myelitis, United States, 2015–2018

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  McLaren, Nilay ; Lopez, Adriana ; Kidd, Sarah ; Zhang, John ; Nix, W. Allan ; Link-Gelles, Ruth ; Lee, Adria ; Routh, Janell A.
• Description:
  Observed peaks of acute flaccid myelitis (AFM) cases have occurred biennially since 2014 in the United States. We aimed to determine if AFM etiology differed between peak and nonpeak years, considering that clinical features of AFM differ by virus etiology. We compared clinical and laboratory characteristics of AFM cases that occurred during peak (2016 and 2018, n = 366) and nonpeak (2015 and 2017, n = 50) years. AFM patients in peak years were younger (5.2 years) than those in nonpeak years (8.3 years). A higher percentage of patients in peak years than nonpeak years had pleocytosis (86% vs. 60%), upper extremity involvement (33% vs. 16%), and an illness preceding limb weakness (90% vs. 62%) and were positive for enterovirus or rhinovirus RNA (38% vs. 16%). Enterovirus D68 infection was associated with AFM only in peak years. Our findings suggest AFM etiology differs between peak and nonpeak years.
• Subjects:
  Adolescent Age Factors Central Nervous System Viral Diseases Child Disease Outbreaks Enterovirus D, Human Enterovirus Infections Female Humans Infant Male Myelitis Neuromuscular Diseases Young Adult

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• Source:
  Emerg Infect Dis. 26(2):212-219
• Pubmed ID:
  31961305
• Pubmed Central ID:
  PMC6986848
• Document Type:
  Journal Article
• Place as Subject:
  United States
• Location:
  North America
• Volume:
  26
• Issue:
  2
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:e1f6a7756eef92f41025fc89fbbcab2d7c8b402a5864f4022b32b70e7517c21d
• Download URL:
  https://stacks.cdc.gov/view/cdc/84845/cdc_84845_DS1.pdf
• File Type:
  [PDF - 735.17 KB ]