Novel Subclone of Carbapenem-Resistant Klebsiella pneumoniae Sequence Type 11 with Enhanced Virulence and Transmissibility, China

Zhou, Kai; Xiao, Tingting; David, Sophia; Wang, Qin; Zhou, Yanzi; Guo, Lihua; Aanensen, David; Holt, Kathryn E.; Thomson, Nicholas R.; Grundmann, Hajo; Shen, Ping; Xiao, Yonghong

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Novel Subclone of Carbapenem-Resistant Klebsiella pneumoniae Sequence Type 11 with Enhanced Virulence and Transmissibility, China

Supporting Files Public Domain

Feb 2020
By Zhou, Kai ; Xiao, Tingting ; David, Sophia ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Zhou, Kai ; Xiao, Tingting ; David, Sophia ; Wang, Qin ; Zhou, Yanzi ; Guo, Lihua ; Aanensen, David ; Holt, Kathryn E. ; Thomson, Nicholas R. ; Grundmann, Hajo ; Shen, Ping ; Xiao, Yonghong
Description:

We aimed to clarify the epidemiologic and clinical importance of evolutionary events that occurred in carbapenem-resistant Klebsiella pneumoniae (CRKP). We collected 203 CRKP causing bloodstream infections in a tertiary hospital in China during 2013-2017. We detected a subclonal shift in the dominant clone sequence type (ST) 11 CRKP in which the previously prevalent capsular loci (KL) 47 had been replaced by KL64 since 2016. Patients infected with ST11-KL64 CRKP had a significantly higher 30-day mortality rate than other CRKP-infected patients. Enhanced virulence was further evidenced by phenotypic tests. Phylogenetic reconstruction demonstrated that ST11-KL64 is derived from an ST11-KL47-like ancestor through recombination. We identified a pLVPK-like virulence plasmid carrying rmpA and peg-344 in ST11-KL64 exclusively from 2016 onward. The pLVPK-like-positive ST11-KL64 isolates exhibited enhanced environmental survival. Retrospective screening of a national collection identified ST11-KL64 in multiple regions. Targeted surveillance of this high-risk CRKP clone is urgently needed.
Subjects:

Adolescent Adult Aged Aged, 80 And Over Anti-Bacterial Agents Carbapenem-Resistant Enterobacteriaceae Drug Resistance, Multiple, Bacterial Female Humans Klebsiella Infections Klebsiella Pneumoniae Male Medical Records Microbial Sensitivity Tests Middle Aged Prevalence Retrospective Studies Survival Analysis Young Adult
Source:

Emerg Infect Dis. 26(2):289-297
Pubmed ID:

31961299
Pubmed Central ID:

PMC6986851
Document Type:

Journal Article
Place as Subject:

China
Location:

Asia
Volume:

26
Issue:

2
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:acc8b21cbc8a838c154424f266e4561750ac62e63aad3cf4f2a6e899bf1d136c
Download URL:

https://stacks.cdc.gov/view/cdc/84827/cdc_84827_DS1.pdf
File Type:

[PDF - 1.06 MB ]

File Language:

English

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