Detection of Avian Influenza A(H7N2) Virus Infection Among Animal Shelter Workers Using a Novel Serological Approach—New York City, 2016–2017

Details

• Alternative Title:
  J Infect Dis
• Personal Author:
  Poirot, Eugenie ; Levine, Min Z. ; Russell, Kate ; Stewart, Rebekah J. ; Pompey, Justine M. ; Chiu, Sophia ; Fry, Alicia M. ; Gross, Liaini ; Havers, Fiona P. ; Li, Zhu-Nan ; Liu, Feng ; Crossa, Aldo ; Lee, Christopher T. ; Boshuizen, Vanessa ; Rakeman, Jennifer L. ; Slavinski, Sally ; Harper, Scott ; Gould, L. Hannah
• Description:
  Background.
  
  In 2016, an influenza A(H7N2) virus outbreak occurred in cats in New York City’s municipal animal shelters. One human infection was initially detected.
  
  Methods.
  
  We conducted a serological survey using a novel approach to rule out cross-reactive antibodies to other seasonal influenza viruses to determine whether additional A(H7N2) human infections had occurred and to assess exposure risk.
  
  Results.
  
  Of 121 shelter workers, one had serological evidence of A(H7N2) infection, corresponding to a seroprevalence of 0.8% (95% confidence interval, .02%–4.5%). Five persons exhibited low positive titers to A(H7N2) virus, indicating possible infection; however, we could not exclude cross-reactive antibody responses to seasonal influenza viruses. The remaining 115 persons were seronegative. The seropositive person reported multiple direct cat exposures without using personal protective equipment and mild illness with subjective fever, runny nose, and sore throat.
  
  Conclusions.
  
  We identified a second case of A(H7N2) infection from this outbreak, providing further evidence of cat-to-human transmission of A(H7N2) virus.
  
  
• Subjects:
  Adult Aged Animals Antibodies, Viral Birds Cats Cross Reactions Disease Outbreaks Female Humans Influenza, Human Influenza A Virus, H7N2 Subtype Influenza In Birds Male Middle Aged New York City Orthomyxoviridae Infections Seroepidemiologic Studies Zoonoses

  More +
• Keywords:
  H7N2 Human Infection Influenza Outbreak Serology Zoonotic
• Source:
  J Infect Dis. 219(11):1688-1696
• Pubmed ID:
  30395249
• Pubmed Central ID:
  PMC6986351
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/ ; U50 CK000407/CK/NCEZID CDC HHSUnited States/
• Volume:
  219
• Issue:
  11
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:f61d3ac458e40714f45662568c1b2594d1e08ac514d19d00bcd6253ab2fba1cd
• Download URL:
  https://stacks.cdc.gov/view/cdc/84630/cdc_84630_DS1.pdf
• File Type:
  [PDF - 272.02 KB ]