Evaluation of Tobacco Smoke and Diet as Sources of Exposure to Two Heterocyclic Aromatic Amines for the U.S. Population: NHANES 2013–2014
Advanced Search
Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.

Search our Collections & Repository

All these words:

For very narrow results

This exact word or phrase:

When looking for a specific result

Any of these words:

Best used for discovery & interchangable words

None of these words:

Recommended to be used in conjunction with other fields

Language:

Dates

Publication Date Range:

to

Document Data

Title:

Document Type:

Library

Collection:

Series:

People

Author:

Help
Clear All

Query Builder

Query box

Help
Clear All

For additional assistance using the Custom Query please check out our Help Page

i

Evaluation of Tobacco Smoke and Diet as Sources of Exposure to Two Heterocyclic Aromatic Amines for the U.S. Population: NHANES 2013–2014

Filetype[PDF-558.68 KB]


  • English
    • Details Supporting Files You May Also Like

    Details:

    • Alternative Title:
      Cancer Epidemiol Biomarkers Prev
    • Personal Author:
    • Description:
      Background:

      Heterocyclic aromatic amines (HAAs) are a group of hazardous substances produced during combustion of tobacco or high-temperature cooking of meats. 2-Amino-9H-pyrido[2,3-b]indole (AαC) is a major carcinogenic HAAs in tobacco smoke.

      Methods:

      Urinary AαC, used as a marker of AαC exposure, was analyzed on spot urine samples from adult participants of the 2013-2014 cycle of the National Health and Nutrition Examination Survey (NHANES; N=1,792). AαC was measured using isotope-dilution liquid chromatography–tandem mass spectrometry. Exclusive combusted tobacco smokers were differentiated from non-users of tobacco products through both self-report and serum cotinine data.

      Results:

      Among exclusive smokers, sample-weighted median urinary AαC was 40 times higher than non-users. Sample-weighted regression models showed that urinary AαC increased significantly with serum cotinine among both exclusive tobacco users and non-users with second-hand smoke exposure. Among non-users, eating beef cooked at high temperature was associated with a significant increase in urinary AαC, while consuming vegetables was associated with decreased AαC. In addition, smoking one-half pack of cigarettes per day was associated with a significant increase of 23.6 pg AαC/mL calculated at geometric mean of AαC, controlling for potential confounders. In comparison, increase in AαC attributable to consuming the 99th percentile of beef cooked at high temperature was 0.99 pg AαC/mL.

      Conclusions:

      Both exclusive smokers and non-users of tobacco in the general U.S. population are exposed to AαC from tobacco smoke, with additional, lesser contributions from certain dietary components.

      Impact:

      AαC is an important biomarker that is associated with tobacco smoke exposure.

    • Subject:
    • Source:
      Cancer Epidemiol Biomarkers Prev. 29(1):103-111
    • Pubmed ID:
      31575556
    • Pubmed Central ID:
      PMC6954285
    • Document Type:
      Journal Article
    • Funding:
      CC999999/ImCDC/Intramural CDC HHS/United States
    • Place as Subject:
      United States
    • Collection(s):
      CDC Public Access
    • Main Document Checksum:
    • File Type:

    You May Also Like

    Checkout today's featured content at stacks.cdc.gov