Tick-Borne Encephalitis Virus, United Kingdom

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Holding, Maya ; Dowall, Stuart D. ; Medlock, Jolyon M. ; Carter, Daniel P. ; Pullan, Steven T. ; Lewis, James ; Vipond, Richard ; Rocchi, Mara S. ; Baylis, Matthew ; Hewson, Roger
• Description:
  During February 2018-January 2019, we conducted large-scale surveillance for the presence and prevalence of tick-borne encephalitis virus (TBEV) and louping ill virus (LIV) in sentinel animals and ticks in the United Kingdom. Serum was collected from 1,309 deer culled across England and Scotland. Overall, 4% of samples were ELISA-positive for the TBEV serocomplex. A focus in the Thetford Forest area had the highest proportion (47.7%) of seropositive samples. Ticks collected from culled deer within seropositive regions were tested for viral RNA; 5 of 2,041 ticks tested positive by LIV/TBEV real-time reverse transcription PCR, all from within the Thetford Forest area. From 1 tick, we identified a full-length genomic sequence of TBEV. Thus, using deer as sentinels revealed a potential TBEV focus in the United Kingdom. This detection of TBEV genomic sequence in UK ticks has important public health implications, especially for undiagnosed encephalitis.
• Subjects:
  Deer Encephalitis, Tick-Borne Encephalitis Viruses, Tick-Borne Enzyme-Linked Immunosorbent Assay Female Hemagglutination Inhibition Tests Humans Ixodidae Male Phylogeny Reverse Transcriptase Polymerase Chain Reaction RNA, Viral Sentinel Species Sequence Analysis, RNA

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• Source:
  Emerg Infect Dis. 26(1):90-96
• Pubmed ID:
  31661056
• Pubmed Central ID:
  PMC6924911
• Document Type:
  Journal Article
• Place as Subject:
  United Kingdom
• Location:
  Europe
• Volume:
  26
• Issue:
  1
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:c7867fd19fc5a1a4b1d5c6c737a4fb45deb52823438ac9e9763c0ee20a96edc9
• Download URL:
  https://stacks.cdc.gov/view/cdc/83900/cdc_83900_DS1.pdf
• File Type:
  [PDF - 1.06 MB ]