Use of benchmark dose models in risk assessment for occupational handlers of eight pesticides used in pome fruit production.

Details

• Alternative Title:
  Regul Toxicol Pharmacol
• Personal Author:
  Pouzou, Jane Gurnick ; Kissel, John ; Yost, Michael G ; Fenske, Richard A ; Cullen, Alison C
• Description:
  The benchmark dose has been frequently recommended for the creation of points of departure for regulatory dose limits, but many regulations, including pesticide risk assessment and registration in the United States, continues to rely on NOAEL methods as the OECD toxicological standard methods recommend. This study used data from studies in support of pesticide registration for eight different compounds to build dose-response models and calculate benchmark doses and confidence limits. The results were compared to the NOAEL of the same study. A probabilistic estimate of dose was compared with all points of departure to demonstrate differences in the protective ability of each different selected limit. While neither the BMD/BMDL nor the NOAEL was consistently more protective, the advantage of using the BMD in quantifying the uncertainty of the point of departure is highlighted, and the feasibility of using current OECD-guideline studies for derivation of a BMD is demonstrated in these cases.
• Subjects:
  Agriculture Animals Benchmarking Farmers Fruit Humans Models, Theoretical No-Observed-Adverse-Effect Level Occupational Exposure Pesticides Risk Assessment

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• Source:
  Regul Toxicol Pharmacol. 110:104504
• Pubmed ID:
  31655092
• Pubmed Central ID:
  PMC6937384
• Document Type:
  Journal Article
• Funding:
  T32 ES007032/ES/NIEHS NIH HHSUnited States/ ; U54 OH007544/OH/NIOSH CDC HHSUnited States/
• Volume:
  110
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:c880dc4adddaee57c6752716711177232fd896822082ab638b2bd1efcc5c2e9ed741f855b7f6caf93b602c06a74423534f439aafacad94bbae095cd1854cc6fe
• Download URL:
  https://stacks.cdc.gov/view/cdc/83856/cdc_83856_DS1.pdf
• File Type:
  [PDF - 724.32 KB ]