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Use of benchmark dose models in risk assessment for occupational handlers of eight pesticides used in pome fruit production.
  • Published Date:
    October 23 2019
  • Source:
    Regul Toxicol Pharmacol. 110:104504
  • Language:
    English


Public Access Version Available on: February 01, 2021, 12:00 AM information icon
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Details:
  • Alternative Title:
    Regul Toxicol Pharmacol
  • Description:
    The benchmark dose has been frequently recommended for the creation of points of departure for regulatory dose limits, but many regulations, including pesticide risk assessment and registration in the United States, continues to rely on NOAEL methods as the OECD toxicological standard methods recommend. This study used data from studies in support of pesticide registration for eight different compounds to build dose-response models and calculate benchmark doses and confidence limits. The results were compared to the NOAEL of the same study. A probabilistic estimate of dose was compared with all points of departure to demonstrate differences in the protective ability of each different selected limit. While neither the BMD/BMDL nor the NOAEL was consistently more protective, the advantage of using the BMD in quantifying the uncertainty of the point of departure is highlighted, and the feasibility of using current OECD-guideline studies for derivation of a BMD is demonstrated in these cases.
  • Subject:
  • Pubmed ID:
    31655092
  • Pubmed Central ID:
    PMC6937384
  • Document Type:
  • Collection(s):
  • Main Document Checksum:
  • Supporting Files:
    No Additional Files
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