Monitoring exposure to polycyclic aromatic hydrocarbons in an Australian population using pooled urine samples

Details

• Alternative Title:
  Environ Int
• Personal Author:
  Thai, Phong K. ; Heffernan, Amy L. ; Toms, Leisa-Maree L. ; Li, Zheng ; Calafat, Antonia M. ; Hobson, Peter ; Broomhall, Sara ; Mueller, Jochen F.
• Description:
  Integrated exposure to polycyclic aromatic hydrocarbons (PAHs) can be assessed through monitoring of urinary mono-hydroxylated PAHs (OH-PAHs). The aim of this study was to provide the first assessment of exposure to PAHs in a large sample of the population in Queensland, Australia including exposure to infant (0-4years). De-identified urine specimens, obtained from a pathology laboratory, were stratified by age and sex, and pooled (n=24 pools of 100) and OH-PAHs were measured by gas chromatography-isotope dilution-tandem mass spectrometry. Geometric mean (GM) concentrations ranged from 30ng/L (4-hydroxyphenanthrene) to 9221ng/L (1-naphthol). GM of 1-hydroxypyrene, the most commonly used PAH exposure biomarker, was 142ng/L. The concentrations of OH-PAHs found in this study are consistent with those in developed countries and lower than those in developing countries. We observed no association between sex and OH-PAH concentrations. However, we observed lower urinary concentrations of all OH-PAHs in samples from infants (0-4years), children (5-14years) and the elderly (>60year old) compared with samples from other age groups (15-29, 30-44 and 45-59years) which may be attributed to age-dependent behaviour-specific exposure sources.
• Subjects:
  Adolescent Adult Aged Biomarkers Child Child, Preschool Chromatography, Gas Environmental Exposure Environmental Monitoring Female Humans Infant Male Middle Aged Naphthols Phenanthrenes Polycyclic Aromatic Hydrocarbons Pyrenes Young Adult

  More +
• Keywords:
  Biomonitoring Exposure Monitoring OH-PAHs Urinary Metabolite
• Source:
  Environ Int. 88:30-35
• Pubmed ID:
  26700419
• Pubmed Central ID:
  PMC6936263
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Place as Subject:
  Queensland, Australia
• Volume:
  88
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:890eca543ef2f3bc7179ac24d9cc13d10d7953553769162b96df32918969c22a
• Download URL:
  https://stacks.cdc.gov/view/cdc/83853/cdc_83853_DS1.pdf
• File Type:
  [PDF - 382.81 KB ]