Characterization of Age-Based Trends to Identify Chemical Biomarkers of Higher Levels in Children

Details

• Alternative Title:
  Environ Int
• Personal Author:
  Nguyen, Vy Kim ; Colacino, Justin A. ; Arnot, Jon A. ; Kvasnicka, Jacob I. ; Jolliet, Olivier
• Description:
  Background:
  
  Chemical biomarker concentrations are driven by complex interactions between chemical use patterns, exposure pathways, and toxicokinetic parameters such as biological half-lives. Criteria to differentiate legacy from current exposures are helpful for interpreting variation in age-based and time trends of chemical exposure and identifying chemicals to which children are highly exposed. A systematic approach is needed to study temporal trends for a wide range of chemicals in the US population.
  
  Objectives:
  
  Using NHANES data on measured biomarker concentrations for 141 chemicals from 1999–2014, we aim to 1) understand the influence of temporal determinants, in particular time trends, biological half-lives, and restriction dates on age-based trends, 2) systematically define an age-based pattern to identify chemicals with ongoing and high exposure in children, and 3) characterize how age-based trends for six Per- and Polyfluoroalkyl Substances (PFASs) are changing over time.
  
  Methods:
  
  We performed an integrated analysis of biological half-lives and restriction dates, compared distributions of chemical biomarker concentrations by age group, and then applied a series of regression models to evaluate the linear (βage) and nonlinear (βage2) relationships between age and chemical biomarker levels.
  
  Results:
  
  For restricted chemicals, a minimum persistence of 1 year in the human body is needed to observe substantial differences between less exposed young population and historically exposed adults. We define a metric (βage2/βage>126.9) that identifies several phthalates, brominated flame retardants, pesticides, and metals such as lead and tungsten to reflect elevated and ongoing exposures in children. While a substantial reduction in children’s exposures was reflected in PFOS and PFOA, levels of PFNA and PFHxS in children were higher in 2013–2014 compared to those in 1999–2000.
  
  Conclusions:
  
  Integrating a series of regression models with systemized stratified analyses by age group enabled us to define an age-based pattern to identify chemicals that are of higher level in children.
  
  
• Subjects:
  Adult Aging Biomarkers Child Environmental Monitoring Environmental Pollutants Female Fluorocarbons Humans Male Nutrition Surveys

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• Keywords:
  Age-based Exposure Biomonitoring Environmental Chemicals Temporal Trends
• Source:
  Environ Int. 122:117-129
• Pubmed ID:
  30528102
• Pubmed Central ID:
  PMC6903703
• Document Type:
  Journal Article
• Funding:
  T42 OH008455/OH/NIOSH CDC HHSUnited States/ ; T32 GM007499/GM/NIGMS NIH HHSUnited States/ ; P30 CA046592/CA/NCI NIH HHSUnited States/ ; R01 ES028802/ES/NIEHS NIH HHSUnited States/ ; T42OH008455/ACL/ACL HHSUnited States/ ; P30 ES017885/ES/NIEHS NIH HHSUnited States/
• Volume:
  122
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:abeb1a14ad091543fc4971cd355b5b282053569647946fbfba3084a3782515a12e44b5e052b7da6a0cac09a6d25e456e20ae2ea1894235e95fb1f38ac350275d
• Download URL:
  https://stacks.cdc.gov/view/cdc/83380/cdc_83380_DS1.pdf
• File Type:
  [PDF - 1.44 MB ]