Genomic Analysis of Fluoroquinolone- and Tetracycline-Resistant Campylobacter jejuni Sequence Type 6964 in Humans and Poultry, New Zealand, 2014–2016

French, Nigel P.; Zhang, Ji; Carter, Glen P.; Midwinter, Anne C.; Biggs, Patrick J.; Dyet, Kristin; Gilpin, Brent J.; Ingle, Danielle J.; Mulqueen, Kerry; Rogers, Lynn E.; Wilkinson, David A.; Greening, Sabrina S.; Muellner, Petra; Fayaz, Ahmed; Williamson, Deborah A.

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Genomic Analysis of Fluoroquinolone- and Tetracycline-Resistant Campylobacter jejuni Sequence Type 6964 in Humans and Poultry, New Zealand, 2014–2016

Supporting Files Public Domain

December 2019
By French, Nigel P. ; Zhang, Ji ; Carter, Glen P. ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

French, Nigel P. ; Zhang, Ji ; Carter, Glen P. ; Midwinter, Anne C. ; Biggs, Patrick J. ; Dyet, Kristin ; Gilpin, Brent J. ; Ingle, Danielle J. ; Mulqueen, Kerry ; Rogers, Lynn E. ; Wilkinson, David A. ; Greening, Sabrina S. ; Muellner, Petra ; Fayaz, Ahmed ; Williamson, Deborah A.
Description:

In 2014, antimicrobial drug-resistant Campylobacter jejuni sequence type 6964 emerged contemporaneously in poultry from 3 supply companies in the North Island of New Zealand and as a major cause of campylobacteriosis in humans in New Zealand. This lineage, not previously identified in New Zealand, was resistant to tetracycline and fluoroquinolones. Genomic analysis revealed divergence into 2 major clades; both clades were associated with human infection, 1 with poultry companies A and B and the other with company C. Accessory genome evolution was associated with a plasmid, phage insertions, and natural transformation. We hypothesize that the tetO gene and a phage were inserted into the chromosome after conjugation, leaving a remnant plasmid that was lost from isolates from company C. The emergence and rapid spread of a resistant clone of C. jejuni in New Zealand, coupled with evolutionary change in the accessory genome, demonstrate the need for ongoing Campylobacter surveillance among poultry and humans.
Subjects:

Antimicrobial Resistance Bacteria Campylobacter Jejuni Fluoroquinolone Genomic Analysis Of Fluoroquinolone- And Tetracycline-Resistant Campylobacter Jejuni Sequence Type 6964 In Humans And Poultry, New Zealand, 2014–2016 New Zealand Plasmid Poultry Research Tetracycline
Source:

Emerg Infect Dis. 25(12):2226-2234
Pubmed ID:

31742539
Pubmed Central ID:

PMC6874264
Document Type:

Journal Article
Volume:

25
Issue:

12
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:5a278e9e4ea7a56052fd1d2e83be07493c4f7665b8fdffb14ae6b1561caaab25
Download URL:

https://stacks.cdc.gov/view/cdc/83296/cdc_83296_DS1.pdf
File Type:

[PDF - 2.66 MB ]

File Language:

English

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