Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
French, Nigel P. ; Zhang, Ji ; Carter, Glen P. ; Midwinter, Anne C. ; Biggs, Patrick J. ; ... More +
French, Nigel P. ; Zhang, Ji ; Carter, Glen P. ; Midwinter, Anne C. ; Biggs, Patrick J. ; Dyet, Kristin ; Gilpin, Brent J. ; Ingle, Danielle J. ; Mulqueen, Kerry ; Rogers, Lynn E. ; Wilkinson, David A. ; Greening, Sabrina S. ; Muellner, Petra ; Fayaz, Ahmed ; Williamson, Deborah A. ; Less -
Description:
In 2014, antimicrobial drug-resistant Campylobacter jejuni sequence type 6964 emerged contemporaneously in poultry from 3 supply companies in the North Island of New Zealand and as a major cause of campylobacteriosis in humans in New Zealand. This lineage, not previously identified in New Zealand, was resistant to tetracycline and fluoroquinolones. Genomic analysis revealed divergence into 2 major clades; both clades were associated with human infection, 1 with poultry companies A and B and the other with company C. Accessory genome evolution was associated with a plasmid, phage insertions, and natural transformation. We hypothesize that the tetO gene and a phage were inserted into the chromosome after conjugation, leaving a remnant plasmid that was lost from isolates from company C. The emergence and rapid spread of a resistant clone of C. jejuni in New Zealand, coupled with evolutionary change in the accessory genome, demonstrate the need for ongoing Campylobacter surveillance among poultry and humans.
Subject:
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Antimicrobial Resistance
Bacteria
Campylobacter Jejuni
Fluoroquinolone
Genomic Analysis Of Fluoroquinolone- And Tetracycline-Resistant Campylobacter Jejuni Sequence Type 6964 In Humans And Poultry, New Zealand, 2014–2016
New Zealand
Plasmid
Poultry
Research
Tetracycline

Source:
Emerg Infect Dis. 25(12):2226-2234
Pubmed ID:
31742539
Pubmed Central ID:
PMC6874264
Document Type:
Journal Article ;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
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urn:sha256:5a278e9e4ea7a56052fd1d2e83be07493c4f7665b8fdffb14ae6b1561caaab25
File Type:

Supporting Files

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