Genomic Analysis of Fluoroquinolone- and Tetracycline-Resistant Campylobacter jejuni Sequence Type 6964 in Humans and Poultry, New Zealand, 2014–2016

French, Nigel P.; Zhang, Ji; Carter, Glen P.; Midwinter, Anne C.; Biggs, Patrick J.; Dyet, Kristin; Gilpin, Brent J.; Ingle, Danielle J.; Mulqueen, Kerry; Rogers, Lynn E.; Wilkinson, David A.; Greening, Sabrina S.; Muellner, Petra; Fayaz, Ahmed; Williamson, Deborah A.

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Genomic Analysis of Fluoroquinolone- and Tetracycline-Resistant Campylobacter jejuni Sequence Type 6964 in Humans and Poultry, New Zealand, 2014–2016

Published Date:

December 2019

Source:

Emerg Infect Dis. 25(12):2226-2234

Language:

English

[PDF-2.66 MB]

Details:

Alternative Title:

Emerg Infect Dis

Personal Author:

French, Nigel P. ; Zhang, Ji ; Carter, Glen P. ; Midwinter, Anne C. ; Biggs, Patrick J. ; ... More ▼

Description:

In 2014, antimicrobial drug-resistant Campylobacter jejuni sequence type 6964 emerged contemporaneously in poultry from 3 supply companies in the North Island of New Zealand and as a major cause of campylobacteriosis in humans in New Zealand. This lineage, not previously identified in New Zealand, was resistant to tetracycline and fluoroquinolones. Genomic analysis revealed divergence into 2 major clades; both clades were associated with human infection, 1 with poultry companies A and B and the other with company C. Accessory genome evolution was associated with a plasmid, phage insertions, and natural transformation. We hypothesize that the tetO gene and a phage were inserted into the chromosome after conjugation, leaving a remnant plasmid that was lost from isolates from company C. The emergence and rapid spread of a resistant clone of C. jejuni in New Zealand, coupled with evolutionary change in the accessory genome, demonstrate the need for ongoing Campylobacter surveillance among poultry and humans.

Subject:

[+]

Pubmed ID:

31742539

Pubmed Central ID:

PMC6874264

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

Main Document Checksum:

[+]

Supporting Files:

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