High Prevalence of Macrolide-Resistant Bordetella pertussis and ptxP1 Genotype, Mainland China, 2014–2016

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Li, Lijun ; Deng, Jikui ; Ma, Xiang ; Zhou, Kai ; Meng, Qinghong ; Yuan, Lin ; Shi, Wei ; Wang, Qing ; Li, Yue ; Yao, Kaihu
• Description:
  According to the government of China, reported cases of pertussis have increased remarkably and are still increasing. To determine the genetic relatedness of Bordetella pertussis strains, we compared multilocus variable-number tandem-repeat analysis (MLVA) results for isolates from China with those from Western countries. Among 335 isolates from China, the most common virulence-associated genotype was ptxA1/ptxC1/ptxP1/prn1/fim2-1/fim3A/tcfA2, which was more frequent among isolates from northern than southern China. Isolates of this genotype were highly resistant to erythromycin. We identified 36 ptxP3 strains mainly harboring ptxA1 and prn2 (35/36); ptxP3 strains were sensitive to erythromycin and were less frequently from northern China. For all isolates, the sulfamethoxazole/trimethoprim MIC was low, indicating that this drug should be recommended for patients infected with erythromycin-resistant B. pertussis. MLVA of 150 clinical isolates identified 13 MLVA types, including 3 predominant types. Our results show that isolates circulating in China differ from those in Western countries.
• Subjects:
  Anti-Bacterial Agents Bordetella Pertussis Child Child, Preschool Drug Resistance, Bacterial Female Genotype Geography, Medical History, 21St Century Humans Infant Infant, Newborn Macrolides Male Multilocus Sequence Typing Mutation Pertussis Vaccine Prevalence Public Health Surveillance Research Rna, Ribosomal, 23S Virulence Whooping Cough/Epidemiology Whooping Cough/History Whooping Cough/Microbiology Whooping Cough/Prevention & Control

  More +
• Source:
  Emerg Infect Dis. 25(12):2205-2214
• Pubmed ID:
  31742507
• Pubmed Central ID:
  PMC6874251
• Document Type:
  Journal Article
• Place as Subject:
  China
• Location:
  Asia
• Volume:
  25
• Issue:
  12
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:b72a979a591a36f005390b462acbd16e1b4f9c21749e6177fd237f20f611c2fb
• Download URL:
  https://stacks.cdc.gov/view/cdc/83291/cdc_83291_DS1.pdf
• File Type:
  [PDF - 2.91 MB ]