Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Li, Lijun ; Deng, Jikui ; Ma, Xiang ; Zhou, Kai ; Meng, Qinghong ; ... More +
Li, Lijun ; Deng, Jikui ; Ma, Xiang ; Zhou, Kai ; Meng, Qinghong ; Yuan, Lin ; Shi, Wei ; Wang, Qing ; Li, Yue ; Yao, Kaihu ; Less -
Description:
According to the government of China, reported cases of pertussis have increased remarkably and are still increasing. To determine the genetic relatedness of Bordetella pertussis strains, we compared multilocus variable-number tandem-repeat analysis (MLVA) results for isolates from China with those from Western countries. Among 335 isolates from China, the most common virulence-associated genotype was ptxA1/ptxC1/ptxP1/prn1/fim2-1/fim3A/tcfA2, which was more frequent among isolates from northern than southern China. Isolates of this genotype were highly resistant to erythromycin. We identified 36 ptxP3 strains mainly harboring ptxA1 and prn2 (35/36); ptxP3 strains were sensitive to erythromycin and were less frequently from northern China. For all isolates, the sulfamethoxazole/trimethoprim MIC was low, indicating that this drug should be recommended for patients infected with erythromycin-resistant B. pertussis. MLVA of 150 clinical isolates identified 13 MLVA types, including 3 predominant types. Our results show that isolates circulating in China differ from those in Western countries.
Subject:
[+]
Anti-Bacterial Agents
Bordetella Pertussis
Child
Child, Preschool
Drug Resistance, Bacterial
Female
Genotype
Geography, Medical
History, 21st Century
Humans
Infant
Infant, Newborn
Macrolides
Male
Multilocus Sequence Typing
Mutation
Pertussis Vaccine
Prevalence
Public Health Surveillance
Research
RNA, Ribosomal, 23S
Virulence
Whooping Cough/epidemiology
Whooping Cough/history
Whooping Cough/microbiology
Whooping Cough/prevention & Control

Source:
Emerg Infect Dis. 25(12):2205-2214 ;
Pubmed ID:
31742507
Pubmed Central ID:
PMC6874251
Document Type:
Journal Article ;
Place as Subject:
China ;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:b72a979a591a36f005390b462acbd16e1b4f9c21749e6177fd237f20f611c2fb
File Type:

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