Tao negatively regulates BMP signaling during neuromuscular junction development in Drosophila

Politano, Stephen F.; Salemme, Ryan R.; Ashley, James; Lopez-Rivera, Javier A.; Bakula, Toren A.; Puhalla, Kathryn A.; Quinn, John P.; Juszczak, Madison J.; Phillip, Lauren K.; Carrillo, Robert A.; Vanderzalm, Pamela J.

doi:10.1002/dneu.22681

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CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners. As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.

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Tao negatively regulates BMP signaling during neuromuscular junction development in Drosophila

4 2019
By Politano, Stephen F. ; Salemme, Ryan R. ; Ashley, James ; ...
http://dx.doi.org/10.1002/dneu.22681
Source: Dev Neurobiol. 79(4):335-349

[PDF-2.38 MB]

English

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Details:

Alternative Title:

Dev Neurobiol
Personal Author:

Politano, Stephen F. ; Salemme, Ryan R. ; Ashley, James ; Lopez-Rivera, Javier A. ; Bakula, Toren A. ; ... More +

Politano, Stephen F. ; Salemme, Ryan R. ; Ashley, James ; Lopez-Rivera, Javier A. ; Bakula, Toren A. ; Puhalla, Kathryn A. ; Quinn, John P. ; Juszczak, Madison J. ; Phillip, Lauren K. ; Carrillo, Robert A. ; Vanderzalm, Pamela J. Less -
Description:

The coordinated growth and development of synapses is critical for all aspects of neural circuit function and mutations that disrupt these processes can result in various neurological defects. Several anterograde and retrograde signaling pathways, including the canonical Bone Morphogenic Protein (BMP) pathway, regulate synaptic development in vertebrates and invertebrates. At the Drosophila larval neuromuscular junction (NMJ), the retrograde BMP pathway is a part of the machinery that controls NMJ expansion concurrent with larval growth. We sought to determine whether the conserved Hippo pathway, critical for proportional growth in other tissues, also functions in NMJ development. We found that neuronal loss of the serine-threonine protein kinase Tao, a regulator of the Hippo signaling pathway, results in supernumerary boutons which contain a normal density of active zones. Tao is also required for proper synaptic function, as reduction of Tao results in NMJs with decreased evoked excitatory junctional potentials. Surprisingly, Tao function in NMJ growth is independent of the Hippo pathway. Instead, our experiments suggest that Tao negatively regulates BMP signaling as reduction of Tao leads to an increase in pMad levels in motor neuron nuclei and an increase in BMP target gene expression. Taken together, these results support a role for Tao as a novel inhibitor of BMP signaling in motor neurons during synaptic development and function.
Subjects:

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Animals Animals, Genetically Modified Bone Morphogenetic Proteins Drosophila Melanogaster Drosophila Proteins Neuromuscular Junction Neuronal Outgrowth Presynaptic Terminals Protein Serine-Threonine Kinases Signal Transduction Synaptic Transmission
Keywords:

[+]

BMP Signaling Hippo Signaling NMJ Development Tao
Source:

Dev Neurobiol. 79(4):335-349
Pubmed ID:

31002474
Pubmed Central ID:

PMC6848449
Document Type:

Journal Article
Funding:

K01 NS102342/NS/NINDS NIH HHSUnited States/ ; P40 OD018537/OD/NIH HHSUnited States/ ; R01 GM084947/GM/NIGMS NIH HHSUnited States/ ; P40 OD018537/CD/ODCDC CDC HHSUnited States/

K01 NS102342/NS/NINDS NIH HHSUnited States/ ; P40 OD018537/OD/NIH HHSUnited States/ ; R01 GM084947/GM/NIGMS NIH HHSUnited States/ ; P40 OD018537/CD/ODCDC CDC HHSUnited States/ Less -
Volume:

79
Issue:

4
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:925f530713d50411455a9ffe6d5dbe1b9e3c15028e3e142fda0c4b67234cc968
Download URL:

https://stacks.cdc.gov/view/cdc/83092/cdc_83092_DS1.pdf
File Type:

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