Race/ethnicity and accuracy of self-reported female first-degree family history of breast and other cancers in the Northern California Breast Cancer Family Registry

Details

• Alternative Title:
  Cancer Epidemiol Biomarkers Prev
• Personal Author:
  John, Esther M. ; Canchola, Alison J. ; Sangaramoorthy, Meera ; Koo, Jocelyn ; Whittemore, Alice S. ; West, Dee W.
• Description:
  Background:
  
  Few studies have evaluated accuracy of self-reported family history of breast and other cancers in racial/ethnic minorities.
  
  Methods:
  
  We assessed the accuracy of cancer family history reports by women with breast cancer (probands) from the Northern California Breast Cancer Family Registry compared to two reference standards: personal cancer history reports by female first-degree relatives and California Cancer Registry records.
  
  Results:
  
  Probands reported breast cancer in first-degree relatives with high accuracy, but accuracy was lower for other cancers. Sensitivity (% correctly identifying relatives with cancer) was 93% (95% CI, 89.5–95.4) when compared to the relatives’ self-report of breast cancer as the reference standard and varied little by proband race/ethnicity and other demographic factors, except for marginally lower sensitivity for Hispanic white probands (87.3%, 95% CI, 78.0–93.1, P=0.07) than non-Hispanic white probands (95.1%, 95% CI=88.9–98.0). Accuracy was also high when compared to cancer registry records as the reference standard, with a sensitivity of 95.5% (95% CI, 93.4–96.9) for breast cancer, but lower sensitivity for Hispanic white probands (91.2%, 95% CI, 84.4–95.2, P=0.05) and probands with low English language proficiency (80%, 95% CI, 52.8–93.5, P <0.01).
  
  Conclusions:
  
  Non-Hispanic white, African American, and Asian American probands reported first-degree breast cancer family history with high accuracy, although sensitivity was lower for Hispanic white probands and those with low English language proficiency.
  
  Impact:
  
  Self-reported family history of breast cancer in first-degree relatives is highly accurate and can be used as a reliable standard when other validation methods are not available.
  
  
• Subjects:
  Adult Breast Neoplasms Female Humans Middle Aged Registries Self Report Young Adult
• Source:
  Cancer Epidemiol Biomarkers Prev. 28(11):1792-1801
• Pubmed ID:
  31488412
• Pubmed Central ID:
  PMC6825587
• Document Type:
  Journal Article
• Funding:
  HHSN261201000036C/CA/NCI NIH HHS/United States ; U01 CA164920/CA/NCI NIH HHS/United States ; U58 DP000807/DP/NCCDPHP CDC HHS/United States
• Place as Subject:
  California
• Volume:
  28
• Issue:
  11
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:be50c0a779ceb81b33126593cc3f3512bd1ca52a66932d60549930d1066496af
• Download URL:
  https://stacks.cdc.gov/view/cdc/83086/cdc_83086_DS1.pdf
• File Type:
  [PDF - 478.50 KB ]