Molecular and Clinical Comparison of Enterovirus D68 Outbreaks among Hospitalized Children, Ohio, USA, 2014 and 2018

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Wang, Huanyu ; Diaz, Alejandro ; Moyer, Katherine ; Mele-Casas, Maria ; Ara-Montojo, Maria Fatima ; Torrus, Isabel ; McCoy, Karen ; Mejias, Asuncion ; Leber, Amy L.
• Description:
  Enterovirus D68 (EV-D68) causes respiratory tract infections and neurologic manifestations. We compared the clinical manifestations from 2 EV-D68 outbreaks in 2014 and 2018 and a low-activity period in 2016 among hospitalized children in central Ohio, USA, and used PCR and sequencing to enable phylogenetic comparisons. During both outbreak periods, infected children had respiratory manifestations that led to an increase in hospital admissions for asthma. The 2018 EV-D68 outbreak appeared to be milder in terms of respiratory illness, as shown by lower rates of pediatric intensive care unit admission. However, the frequency of severe neurologic manifestations was higher in 2018 than in 2014. During the same period in 2016, we noted neither an increase in EV-D68 nor a significant increase in asthma-related admissions. Phylogenetic analyses showed that EV-D68 isolates from 2018 clustered differently within clade B than did isolates from 2014 and are perhaps associated with a different EV-D68 subclade.
• Subjects:
  Asthma Child Child, Preschool Comorbidity Cross Infection Disease Outbreaks Enterovirus D, Human Enterovirus Infections/Diagnosis Enterovirus Infections/Epidemiology Enterovirus Infections/History Enterovirus Infections/Virology Female History, 21St Century Humans Infant Male Molecular Typing Phylogeny Public Health Surveillance Respiratory Tract Infections Seasons

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• Source:
  Emerg Infect Dis. 25(11):2055-2063
• Pubmed ID:
  31454311
• Pubmed Central ID:
  PMC6810223
• Document Type:
  Journal Article
• Genre:
  Historical Article
• Place as Subject:
  Ohio
• Volume:
  25
• Issue:
  11
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:5d7af2cc2478d6ba9f030b1f3f0ec769bb608c84fb0b705326eb86e1d5f588c2
• Download URL:
  https://stacks.cdc.gov/view/cdc/83016/cdc_83016_DS1.pdf
• File Type:
  [PDF - 2.19 MB ]