Lack of Efficacy of High-Titered Immunoglobulin in Patients with West Nile Virus Central Nervous System Disease

Gnann, John W.; Agrawal, Amy; Hart, John; Buitrago, Martha; Carson, Paul; Hanfelt-Goade, Diane; Tyler, Ken; Spotkov, Jared; Freifeld, Alison; Moore, Thomas; Reyno, Jorge; Masur, Henry; Jester, Penelope; Dale, Ilet; Li, Yufeng; Aban, Inmaculada; Lakeman, Fred D.; Whitley, Richard J.

Advanced Search

Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.

Search our Collections & Repository

Advanced Search
Custom Query

All these words:

For very narrow results

This exact word or phrase:

When looking for a specific result

Any of these words:

Best used for discovery & interchangable words

None of these words:

Recommended to be used in conjunction with other fields

Language:

Dates

Publication Date Range:

to

Document Data

Title:

Document Type:

Library

Collection:

Series:

People

Author:

Clear All

Query Builder

Query box

Clear All

For additional assistance using the Custom Query please check out our Help Page

i

Lack of Efficacy of High-Titered Immunoglobulin in Patients with West Nile Virus Central Nervous System Disease

November 2019
By Gnann, John W. ; Agrawal, Amy ; Hart, John ; ...
Source: Emerg Infect Dis. 25(11):2064-2073

[PDF-1004.41 KB]

English

Details Supporting Files You May Also Like

Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

Gnann, John W. ; Agrawal, Amy ; Hart, John ; Buitrago, Martha ; Carson, Paul ; ... More +

Gnann, John W. ; Agrawal, Amy ; Hart, John ; Buitrago, Martha ; Carson, Paul ; Hanfelt-Goade, Diane ; Tyler, Ken ; Spotkov, Jared ; Freifeld, Alison ; Moore, Thomas ; Reyno, Jorge ; Masur, Henry ; Jester, Penelope ; Dale, Ilet ; Li, Yufeng ; Aban, Inmaculada ; Lakeman, Fred D. ; Whitley, Richard J. Less -
Corporate Authors:

for the National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group
Description:

West Nile Virus (WNV) can result in clinically severe neurologic disease. There is no treatment for WNV infection, but administration of anti-WNV polyclonal human antibody has demonstrated efficacy in animal models. We compared Omr-IgG-am, an immunoglobulin product with high titers of anti-WNV antibody, with intravenous immunoglobulin (IVIG) and normal saline to assess safety and efficacy in patients with WNV neuroinvasive disease as part of a phase I/II, randomized, double-blind, multicenter study in North America. During 2003-2006, a total of 62 hospitalized patients were randomized to receive Omr-IgG-am, standard IVIG, or normal saline (3:1:1). The primary endpoint was medication safety. Secondary endpoints were morbidity and mortality, measured using 4 standardized assessments of cognitive and functional status. The death rate in the study population was 12.9%. No significant differences were found between groups receiving Omr-IgG-am compared with IVIG or saline for either the safety or efficacy endpoints.
Subjects:

[+]

Central Nervous System Disease Encephalitis Flavivirus Immunoglobulin Lack Of Efficacy Of High-Titered Immunoglobulin In Patients With West Nile Virus Central Nervous System Disease Neuroinvasive Disease Omr-IgG-am Polygam Research Viruses West Nile Virus WNV
Source:

Emerg Infect Dis. 25(11):2064-2073
Pubmed ID:

31625835
Pubmed Central ID:

PMC6810207
Document Type:

Journal Article
Place as Subject:

North America
Location:

North America
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

[+]

urn:sha256:7258a240302fc06e7c760a53d342cfa1b71549bcf85de30a01b1dee746902c4b
Download URL:

https://stacks.cdc.gov/view/cdc/83001/cdc_83001_DS1.pdf
File Type:

	19-0537-F.gif	gif
	19-0537-F.jpg	jpeg
	19-0537-Techapp-s1.pdf	pdf
	19-0537.nxml	xml

More +