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Early Diagnosis of Tularemia by Flow Cytometry, Czech Republic, 2003–20151
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October 2019
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Source: Emerg Infect Dis. 25(10):1919-1927
[PDF-1.22 MB]
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Alternative Title:Emerg Infect Dis
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Description:We retrospectively assessed the utility of a flow cytometry-based test quantifying the percentage of CD3+ T cells with the CD4-/CD8- phenotype for predicting tularemia diagnoses in 64 probable and confirmed tularemia patients treated during 2003-2015 and 342 controls with tularemia-like illnesses treated during 2012-2015 in the Czech Republic. The median percentage of CD3+/CD4-/CD8- T cells in peripheral blood was higher in tularemia patients (19%, 95% CI 17%-22%) than in controls (3%, 95% CI 2%-3%). When we used 8% as the cutoff, this test's sensitivity was 0.953 and specificity 0.895 for distinguishing cases from controls. The CD3+/CD4-/CD8- T cells increased a median of 7 days before tularemia serologic test results became positive. This test supports early presumptive diagnosis of tularemia for clinically suspected cases 7-14 days before diagnosis can be confirmed by serologic testing in regions with low prevalences of tularemia-like illnesses.
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Pubmed ID:31538915
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Pubmed Central ID:PMC6759275
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Document Type:
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Volume:25
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Issue:10
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