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PATERNAL AND JOINT PARENTAL OCCUPATIONAL PESTICIDE EXPOSURE AND SPINA BIFIDA IN THE NATIONAL BIRTH DEFECTS PREVENTION STUDY, 1997-2002
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Nov 2016
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Source: Birth Defects Res A Clin Mol Teratol. 106(11):963-971
Details:
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Alternative Title:Birth Defects Res A Clin Mol Teratol
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Personal Author:
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Description:Objective:
Because of persistent concerns over the association between pesticides and spina bifida, we examined the role of paternal occupational pesticide exposure and combined parental occupational pesticide exposures in spina bifida in offspring using data from a large population-based study of birth defects.
Design:
Case-control
Methods:
Occupational information from fathers of 291 spina bifida cases and 2745 unaffected live born control infants with estimated dates of delivery from 1997–2002 were collected via maternal report. Estimated exposure intensity and frequency to insecticides, herbicides, and fungicides were independently assigned by two expert industrial hygienists, blinded to case or control status, with disagreements resolved by consensus. Multivariable logistic regression models were used to estimate adjusted odds ratios (aOR) and 95% confidence intervals (CI) for exposure to any pesticide and to any class of pesticide (yes/no; and by median), and exposure to combinations of pesticides (yes/no) and risk of spina bifida. Adjusted odds ratios were also estimated by parent exposed to pesticides (neither, mother only, father only, both parents).
Results:
Joint parental occupational pesticide exposure was positively associated with spina bifida (aOR 1.5, 95% CI 0.9–2.4) when compared to infants with neither maternal nor paternal exposures; a similar association was not observed when only one parent was exposed. There was a suggested positive association between combined paternal insecticide and fungicide exposures and spina bifida (aOR 1.5, 95% CI 0.8–2.8), however nearly all other aORs for spina bifida and paternal pesticide exposures were close to unity.
Conclusions:
Overall, there was little evidence that paternal occupational pesticide exposure was associated with spina bifida. Joint parental occupational pesticide exposure was associated with spina bifida, as was paternal occupational exposure to a combination of insecticides and fungicides. However, the small numbers make it difficult to precisely evaluate the role of pesticide classes, individually and in combination.
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Source:
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Pubmed ID:27891778
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Pubmed Central ID:PMC6613649
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Document Type:
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Funding:
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Volume:106
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Issue:11
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