Long-term outcomes of Guillain-Barré syndrome possibly associated with Zika virus infection

Details

• Alternative Title:
  PLoS One
• Personal Author:
  Walteros, Diana M. ; Soares, Jesus ; Styczynski, Ashley R. ; Abrams, Joseph Y. ; Galindo-Buitrago, Jose I. ; Acosta-Reyes, Jorge ; Bravo-Ribero, Elsa ; Arteta, Zuleima E. ; Solano-Sanchez, Alma ; Prieto, Franklyn E. ; Gonzalez-Duarte, Maritza ; Navarro-Lechuga, Edgar ; Salinas, Jorge L. ; Belay, Ermias D. ; Schonberger, Lawrence B. ; Damon, Inger K. ; Ospina, Martha L. ; Sejvar, James J.
• Description:
  Background
  
  This prospective cohort investigation analyzed the long-term functional and neurologic outcomes of patients with Zika virus-associated Guillain-Barré syndrome (GBS) in Barranquilla, Colombia.
  
  Methods
  
  Thirty-four Zika virus-associated GBS cases were assessed a median of 17 months following acute GBS illness. We assessed demographics, results of Overall Disability Sum Scores (ODSS), Hughes Disability Score (HDS), Zung Depression Scale (ZDS), and Health Related Quality of Life (HRQL) questionnaires; and compared outcomes indices with a normative sample of neighborhood-selected control subjects in Barranquilla without GBS.
  
  Results
  
  Median age at time of acute neurologic onset was 49 years (range, 10–80); 17 (50%) were male. No deaths occurred. At long-term follow-up, 25 (73%) patients had a HDS 0–1, indicating complete / near complete recovery. Among the group, HDS (mean 1.4, range 0–4), ODSS (mean 1.9, range 0–9) and ZDS score (mean 34.4, range 20–56) indicated mild / moderate ongoing disability. Adjusting for age and sex, Zika virus-associated GBS cases were similar to a population comparison group (n = 368) in Barranquilla without GBS in terms of prevalence of physical or mental health complaints, though GBS patients were more likely to have an ODSS of ≥ 1 (OR 8.8, 95% CI 3.2–24.5) and to suffer from moderate / moderate-severe depression (OR 3.89, 95% CI 1.23–11.17) than the comparison group.
  
  Conclusions
  
  Long-term outcomes of Zika virus-associated GBS are consistent with those associated with other antecedent antigenic stimuli in terms of mortality and ongoing long-term morbidity, as published in the literature. Persons with Zika virus-associated GBS more frequently reported disability and depression after approximately one year compared with those without GBS.
  
  
• Subjects:
  Adolescent Adult Aged Aged, 80 And Over Child Depression Disease Outbreaks Female Follow-Up Studies Guillain-Barre Syndrome Humans Incidence Male Middle Aged Prognosis Prospective Studies Quality Of Life Young Adult Zika Virus Zika Virus Infection

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• Source:
  PLoS One. 14(8)
• Pubmed ID:
  31369576
• Pubmed Central ID:
  PMC6675241
• Document Type:
  Journal Article
• Place as Subject:
  United States
• Volume:
  14
• Issue:
  8
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:8bf260b77520b6762ff07d16468a18bf53b3fe2e244772b9c1130ba13667e5ed
• Download URL:
  https://stacks.cdc.gov/view/cdc/81921/cdc_81921_DS1.pdf
• File Type:
  [PDF - 1.34 MB ]