Study of Environment, Lifestyle and Fibroids

Details

• Alternative Title:
  J Expo Sci Environ Epidemiol
• Personal Author:
  Bethea, Traci N. ; Wesselink, Amelia K. ; Weuve, Jennifer ; McClean, Michael D. ; Hauser, Russ ; Williams, Paige L. ; Ye, Xiaoyun ; Calafat, Antonia M. ; Baird, Donna D. ; Wise, Lauren A.
• Description:
  We performed a cross-sectional analysis to identify correlates of urinary concentrations of seven phenols (bisphenols A, F, and S; 2,4-dichlorophenol; 2,5-dichlorophenol; benzophenone-3; triclosan), triclocarban, and four parabens (butyl, ethyl, methyl, and propyl). We analyzed baseline data from 766 participants in the Study of Environment, Lifestyle, and Fibroids, a prospective cohort study of 1693 Black women aged 23-34 years residing in Detroit, Michigan (2010-2012). We collected data on demographic, behavioral, and anthropometric factors via telephone interviews, clinic visits, and self-administered questionnaires. For each biomarker, we used linear regression models to estimate mean differences in log-transformed, creatinine-corrected concentrations across factors of interest. Each biomarker was detected in >50% of participants. Median creatinine-corrected concentrations were the highest for methyl paraben (116.8 μg/g creatinine), propyl paraben (16.8 μg/g creatinine), and benzophenone-3 (13.4 μg/g creatinine). Variables most strongly associated with biomarker concentrations included season of urine collection, education, and body mass index (BMI). BMI was positively associated with bisphenol A and S and triclocarban concentrations and inversely associated with butyl and methyl paraben concentrations. In this cohort of Black women, exposure to phenols, parabens, and triclocarban was prevalent and several factors were associated with biomarker concentrations.
• Subjects:
  Article Endocrine Disruptors Epidemiology Personal Exposure Population-based Studies
• Source:
  J Expo Sci Environ Epidemiol.
• Pubmed ID:
  30692588
• Pubmed Central ID:
  PMC6661224
• Document Type:
  Journal Article
• Funding:
  R01 ES024749/ES/NIEHS NIH HHS/United States
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:b31f6ace320ba7025aefdd8a8ce3eff4a83d23964223f66188c94e876a03c16d
• Download URL:
  https://stacks.cdc.gov/view/cdc/81690/cdc_81690_DS1.pdf
• File Type:
  [PDF - 477.71 KB ]