A Common HLA-DPA1 Variant Is Associated with Hepatitis B Virus Infection but Fails to Distinguish Active from Inactive Caucasian Carriers

Details

• Alternative Title:
  PLoS One
• Personal Author:
  Vermehren, Johannes ; Lötsch, Jörn ; Susser, Simone ; Wicker, Sabine ; Berger, Annemarie ; Zeuzem, Stefan ; Sarrazin, Christoph ; Doehring, Alexandra
• Description:
  Background and Aims
  
  Chronic infection with the hepatitis B virus (HBV) is a major health issue worldwide. Recently, single nucleotide polymorphisms (SNPs) within the human leukocyte antigen (HLA)-DP locus were identified to be associated with HBV infection in Asian populations. Most significant associations were observed for the A alleles of HLA-DPA1 rs3077 and HLA-DPB1 rs9277535, which conferred a decreased risk for HBV infection. We assessed the implications of these variants for HBV infection in Caucasians.
  
  Methods
  
  Two HLA-DP gene variants (rs3077 and rs9277535) were analyzed for associations with persistent HBV infection and with different clinical outcomes, i.e., inactive HBsAg carrier status versus progressive chronic HBV (CHB) infection in Caucasian patients (n = 201) and HBsAg negative controls (n = 235).
  
  Results
  
  The HLA-DPA1 rs3077 C allele was significantly associated with HBV infection (odds ratio, OR = 5.1, 95% confidence interval, CI: 1.9–13.7; p = 0.00093). However, no significant association was seen for rs3077 with progressive CHB infection versus inactive HBsAg carrier status (OR = 2.7, 95% CI: 0.6–11.1; p = 0.31). In contrast, HLA-DPB1 rs9277535 was not associated with HBV infection in Caucasians (OR = 0.8, 95% CI: 0.4–1.9; p = 1).
  
  Conclusions
  
  A highly significant association of HLA-DPA1 rs3077 with HBV infection was observed in Caucasians. However, as a differentiation between different clinical courses of HBV infection was not possible, knowledge of the HLA-DPA1 genotype cannot be translated into personalized anti-HBV therapy approaches.
  
  
• Subjects:
  Adult Alleles Asian People Case-Control Studies DNA, Viral Female Genetic Predisposition To Disease Genotype Haplotypes Hepatitis B Hepatitis B Surface Antigens Hepatitis B Virus Heterozygote HLA-DP Alpha-Chains Humans Male Polymerase Chain Reaction Polymorphism, Single Nucleotide White People

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• Source:
  PLoS One. 2012; 7(3).
• Document Type:
  Journal Article
• Volume:
  7
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:9a6a711bf4eaae987d5419b4a01a3256b228f1b7e125c9596fecfdd5ca14adb4
• Download URL:
  https://stacks.cdc.gov/view/cdc/8160/cdc_8160_DS1.pdf
• File Type:
  [PDF - 83.79 KB ]