Lifestyle of women before pregnancy and the risk of offspring obesity during childhood through early adulthood

Details

• Alternative Title:
  Int J Obes (Lond)
• Personal Author:
  Dhana, Klodian ; Zong, Geng ; Yuan, Changzheng ; Schernhammer, Eva ; Zhang, Cuilin ; Wang, Xiaobin ; Hu, Frank B. ; Chavarro, Jorge E. ; Field, Alison E. ; Sun, Qi
• Description:
  Background:
  
  In women, adhering to an overall healthy lifestyle is associated with a dramatically reduced risk of cardio-metabolic disorders. Whether such a healthy lifestyle exerts an intergenerational effects on child health deserves examination.
  
  Methods:
  
  We included 5,701 children (9-14 years old at baseline) of the Growing Up Today Study 2, and their mothers, who are participants in the Nurses’ Health Study II. Pre-pregnancy healthy lifestyle was defined as a normal body mass index, no-smoking, physical activity ≥150min/week, and diet in the top 40% of the Alternative Healthy Eating Index–2010. Obesity during childhood and adolescence was defined using the International Obesity Task Force age- and sex-specific cutoffs. Multivariable log-binominal regression models with generalized estimating equations were used to evaluate the association of pre-pregnancy healthy lifestyle and offspring obesity.
  
  Results:
  
  We identified 520 (9.1%) offspring who became obese during follow-up. A healthy body weight of mothers and no smoking before pregnancy were significantly associated with a lower risk of obesity among offspring: the relative risks [RRs; 95% confidence intervals (CIs)] were 0.37 (0.31-0.43) and 0.64 (0.49-0.84), respectively. Eating a healthy diet and regular moderate-to-vigorous physical activities were inversely related to offspring obesity risk, but these relations were not statistically significant. Compared to children of mothers who did not meet any low-risk lifestyle factors, offspring of women who adhered to all four healthy lifestyle factors had 75% lower risk of obesity (RR 0.25, 95%CI 0.14-0.43).
  
  Conclusion:
  
  Adherence to an overall healthy lifestyle before pregnancy is strongly associated with a low risk of offspring obesity in childhood, adolescence, and early adulthood. These findings highlight the importance of an overall healthy lifestyle before pregnancy as a potential strategy to prevent obesity in future generations.
  
  
• Subjects:
  Adolescent Adult Article Body Mass Index Body Weight Child Child, Preschool Female Follow-Up Studies Healthy Lifestyle Humans Male Mothers Pediatric Obesity Preconception Care Pregnancy Prospective Studies Surveys And Questionnaires

  More +
• Source:
  Int J Obes (Lond). 42(7):1275-1284
• Pubmed ID:
  29568108
• Pubmed Central ID:
  PMC6727198
• Document Type:
  Journal Article
• Funding:
  P30 DK046200/DK/NIDDK NIH HHS/United States ; R01 ES021372/ES/NIEHS NIH HHS/United States ; R01 HD066963/HD/NICHD NIH HHS/United States ; R01 MH087786/MH/NIMH NIH HHS/United States ; R01 HL035464/HL/NHLBI NIH HHS/United States ; R01OH009803/ACL HHS/United States ; R01 DK084001/DK/NIDDK NIH HHS/United States ; R01 ES022981/ES/NIEHS NIH HHS/United States ; R01 HL096905/HL/NHLBI NIH HHS/United States ; R01 OH009803/OH/NIOSH CDC HHS/United States ; R01 HL034594/HL/NHLBI NIH HHS/United States ; U01 CA176726/CA/NCI NIH HHS/United States ; UM1 CA176726/CA/NCI NIH HHS/United States ; T32 DK007703/DK/NIDDK NIH HHS/United States ; U54 CA155626/CA/NCI NIH HHS/United States
• Volume:
  42
• Issue:
  7
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:e8dfd578f0fb9a469bd628f5a0d7b3f43930e636cb0d54fb7a5d542f04ea5b3a
• Download URL:
  https://stacks.cdc.gov/view/cdc/81246/cdc_81246_DS1.pdf
• File Type:
  [PDF - 147.49 KB ]