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Epidemiology of Carbapenemase-Producing Klebsiella pneumoniae in a Hospital, Portugal
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Sep 2019
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Source: Emerg Infect Dis. 25(9):1632-1638
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Alternative Title:Emerg Infect Dis
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Description:We aimed to provide updated epidemiologic data on carbapenem-resistant Klebsiella pneumoniae in Portugal by characterizing all isolates (N = 46) recovered during 2013-2018 in a 123-bed hospital in Lisbon. We identified bla| (n = 36), bla| (n = 9), and bla| (n = 8) carbapenemase genes and observed co-occurrence of bla| and bla| in 7 isolates. A single GES-5-producing isolate co-produced the extended-spectrum β-lactamase BEL-1; both corresponding genes were co-located on the same ColE1-like plasmid. The bla| gene was always located on an IncX3 plasmid, whereas bla| was carried on IncN, IncFII, IncFIB, and IncFIIA plasmid types. The 46 isolates were distributed into 13 pulsotypes and 9 sequence types. All isolates remained susceptible to ceftazidime/avibactam, but some exhibited reduced antimicrobial susceptibility (MIC = 3 mg/L).
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Pubmed ID:31441424
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Pubmed Central ID:PMC6711212
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