Association of Enterovirus D68 with Acute Flaccid Myelitis, Philadelphia, Pennsylvania, USA, 2009–2018

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Uprety, Priyanka ; Curtis, Darcy ; Elkan, Michael ; Fink, Jeffrey ; Rajagopalan, Ramakrishnan ; Zhao, Chunyu ; Bittinger, Kyle ; Mitchell, Stephanie ; Ulloa, Erlinda R. ; Hopkins, Sarah ; Graf, Erin H.
• Description:
  Acute flaccid myelitis (AFM) is a polio-like disease that results in paralysis in previously healthy persons. Although the definitive cause of AFM remains unconfirmed, enterovirus D68 (EV-D68) is suspected based on 2014 data demonstrating an increase in AFM cases concomitant with an EV-D68 outbreak. We examined the prevalence in children and the molecular evolution of EV-D68 for 2009-2018 in Philadelphia, Pennsylvania, USA. We detected widespread EV-D68 circulation in 2009, rare detections in 2010 and 2011, and then biennial circulation, only in even years, during 2012-2018. Prevalence of EV-D68 significantly correlated with AFM cases during this period. Finally, whole-genome sequencing revealed early detection of the B1 clade in 2009 and continued evolution of the B3 clade from 2016 to 2018. These data reinforce the need to improve surveillance programs for nonpolio enterovirus to identify possible AFM triggers and predict disease prevalence to better prepare for future outbreaks.
• Subjects:
  Acute Flaccid Myelitis Children Enterovirus Enterovirus D68 EV-D68 Expedited Research Viruses Whole-genome Sequencing
• Source:
  Emerg Infect Dis. 25(9):1676-1682
• Pubmed ID:
  31407660
• Pubmed Central ID:
  PMC6711208
• Document Type:
  Journal Article
• Place as Subject:
  Philadelphia, Pennsylvania
• Location:
  North America
• Volume:
  25
• Issue:
  9
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:74c6ac013c5c71a5e638d533dcc5d1d07ee597a7fef3160d47a61ad4b8701501
• Download URL:
  https://stacks.cdc.gov/view/cdc/81174/cdc_81174_DS1.pdf
• File Type:
  [PDF - 1.32 MB ]