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Genotyping Approach for Potential Common Source of Enterocytozoon bieneusi Infection in Hematology Unit
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September 2019
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Source: Emerg Infect Dis. 25(9):1625-1631
[PDF-1.20 MB]
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Alternative Title:Emerg Infect Dis
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Description:Microsporidiosis is a fungal infection that generally causes digestive disorders, especially in immunocompromised hosts. Over a 4-day period in January 2018, 3 patients with hematologic malignancies who were admitted to the hematology unit of a hospital in France received diagnoses of Enterocytozoon bieneusi microsporidiosis. This unusually high incidence was investigated by sequence analysis at the internal transcribed spacer rDNA locus and then by 3 microsatellites and 1 minisatellite for multilocus genotyping. The 3 isolates had many sequence similarities and belonged to a new genotype closely related to genotype C. In addition, multilocus genotyping showed high genetic distances with all the other strains collected from epidemiologically unrelated persons; none of these strains belonged to the new genotype. These data confirm the epidemiologic link among the 3 patients and support a common source of infection.
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Pubmed ID:31441425
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Pubmed Central ID:PMC6711236
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