Genotyping Approach for Potential Common Source of Enterocytozoon bieneusi Infection in Hematology Unit

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Desoubeaux, Guillaume ; Nourrisson, Céline ; Moniot, Maxime ; De Kyvon, Marie-Alix ; Bonnin, Virginie ; De La Bretonniére, Marjan Ertault ; Morange, Virginie ; Bailly, Éric ; Lemaignen, Adrien ; Morio, Florent ; Poirier, Philippe
• Description:
  Microsporidiosis is a fungal infection that generally causes digestive disorders, especially in immunocompromised hosts. Over a 4-day period in January 2018, 3 patients with hematologic malignancies who were admitted to the hematology unit of a hospital in France received diagnoses of Enterocytozoon bieneusi microsporidiosis. This unusually high incidence was investigated by sequence analysis at the internal transcribed spacer rDNA locus and then by 3 microsatellites and 1 minisatellite for multilocus genotyping. The 3 isolates had many sequence similarities and belonged to a new genotype closely related to genotype C. In addition, multilocus genotyping showed high genetic distances with all the other strains collected from epidemiologically unrelated persons; none of these strains belonged to the new genotype. These data confirm the epidemiologic link among the 3 patients and support a common source of infection.
• Subjects:
  Cluster Enterocytozoon Bieneusi Epidemiology France Fungi Genotyping Genotyping Approach For Potential Common Source Of Enterocytozoon Bieneusi Infection In Hematology Unit ITS RDNA Microsporidia Microsporidiosis Outbreak Satellites Synopsis

  More +
• Source:
  Emerg Infect Dis. 25(9):1625-1631
• Pubmed ID:
  31441425
• Pubmed Central ID:
  PMC6711236
• Document Type:
  Journal Article
• Volume:
  25
• Issue:
  9
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:a6a3b1cc5041128615484cb625efa697bbc120f4f48980de9ea1d6816ed5d303
• Download URL:
  https://stacks.cdc.gov/view/cdc/81167/cdc_81167_DS1.pdf
• File Type:
  [PDF - 1.20 MB ]