Use of Human Intestinal Enteroids to Detect 
Human Norovirus Infectivity

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Chan, Martin Chi-Wai ; Cheung, Sarah K.C. ; Mohammad, Kirran N. ; Chan, Jenny C.M. ; Estes, Mary K. ; Chan, Paul K.S.
• Description:
  Tools to detect human norovirus infectivity have been lacking. Using human intestinal enteroid cultures inoculated with GII.Pe-GII.4 Sydney-infected fecal samples, we determined that a real-time reverse transcription PCR cycle threshold cutoff of 30 may indicate infectious norovirus. This finding could be used to help guide infection control.
• Subjects:
  Ct Cutoff Cycle Threshold Dispatch Enteric Infections Enteroids Human Norovirus Infectivity Real-time Reverse Transcription PCR RRT-PCR Use Of Human Intestinal Enteroids To Determine Human Norovirus Infectivity Viruses

  More +
• Source:
  Emerg Infect Dis. 25(9):1730-1735
• Pubmed ID:
  31441758
• Pubmed Central ID:
  PMC6711227
• Document Type:
  Journal Article
• Funding:
  P01 AI057788/AI/NIAID NIH HHS/United States
• Place as Subject:
  Hong Kong
• Location:
  Asia
• Volume:
  25
• Issue:
  9
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:4446067c584c9aad618aebef34016066886a096353b4221dbceca2c012034ff1
• Download URL:
  https://stacks.cdc.gov/view/cdc/81163/cdc_81163_DS1.pdf
• File Type:
  [PDF - 1.04 MB ]