Decision Tool for Herpes B Virus Antiviral Prophylaxis after Macaque-Related Injuries in Research Laboratory Workers

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Barkati, Sapha ; Taher, Hashim Ba ; Beauchamp, Elizabeth ; Yansouni, Cédric P. ; Ward, Brian J. ; Libman, Michael D.
• Description:
  Macaque-related injuries among primate workers can lead to a potentially fatal B virus encephalomyelitis. We describe a decision tool for evaluating the need for antiviral postexposure prophylaxis and provide a retrospective review of the injuries assessed in our center after its implementation in 2010. Among the injuries studied (n = 251), 40.6% were categorized as high-risk (prophylaxis recommended), 44.2% moderate-risk (consider prophylaxis), and 15.1% low-risk (prophylaxis not recommended). Ten percent of low-risk and 98% of high-risk injuries received prophylaxis (p<0.001). Compared with using universal postexposure prophylaxis, using a decision tool can lead to a standardization of practice and a reduction in prescriptions for antiviral medication.
• Subjects:
  Antiviral Agents B Virus Decision Tool Herpes B Virus Infection Macacine Alphaherpesvirus 1 Macaque Monkey B Virus Online Report Post-exposure Prophylaxis Primate Workers Research Laboratory Workers Viruses

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• Source:
  Emerg Infect Dis. 25(9)
• Pubmed ID:
  31441751
• Pubmed Central ID:
  PMC6711206
• Document Type:
  Journal Article
• Volume:
  25
• Issue:
  9
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:8f4acbd6f0e69611dd29bc89e4a780a5a7727cf2e0a3d25cacbeb12be0cf72bb
• Download URL:
  https://stacks.cdc.gov/view/cdc/81158/cdc_81158_DS1.pdf
• File Type:
  [PDF - 1.19 MB ]