Epidemiologic Shift in Candidemia Driven by Candida auris, South Africa, 2016–20171

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  van Schalkwyk, Erika ; Mpembe, Ruth S. ; Thomas, Juno ; Shuping, Liliwe ; Ismail, Husna ; Lowman, Warren ; Karstaedt, Alan S. ; Chibabhai, Vindana ; Wadula, Jeannette ; Avenant, Theunis ; Messina, Angeliki ; Govind, Chetna N. ; Moodley, Krishnee ; Dawood, Halima ; Ramjathan, Praksha ; Govender, Nelesh P.
• Corporate Authors:
  for GERMS-SA
• Description:
  Candida auris is an invasive healthcare-associated fungal pathogen. Cases of candidemia, defined as illness in patients with Candida cultured from blood, were detected through national laboratory-based surveillance in South Africa during 2016-2017. We identified viable isolates by using mass spectrometry and sequencing. Among 6,669 cases (5,876 with species identification) from 269 hospitals, 794 (14%) were caused by C. auris. The incidence risk for all candidemia at 133 hospitals was 83.8 (95% CI 81.2-86.4) cases/100,000 admissions. Prior systemic antifungal drug therapy was associated with a 40% increased adjusted odds of C. auris fungemia compared with bloodstream infection caused by other Candida species (adjusted odds ratio 1.4 [95% CI 0.8-2.3]). The crude in-hospital case-fatality ratio did not differ between Candida species and was 45% for C. auris candidemia, compared with 43% for non-C. auris candidemia. C. auris has caused a major epidemiologic shift in candidemia in South Africa.
• Subjects:
  Adolescent Adult Aged Antifungal Agents Candida Candidiasis Child Child, Preschool Drug Resistance, Fungal Female Humans Incidence Infant Infant, Newborn Male Middle Aged Risk Factors Young Adult

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• Source:
  Emerg Infect Dis. 25(9):1698-1707
• Pubmed ID:
  31441749
• Pubmed Central ID:
  PMC6711229
• Document Type:
  Journal Article
• Place as Subject:
  South Africa
• Location:
  Africa
• Volume:
  25
• Issue:
  9
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:536300601d08acabfbe29bb803c0609e1c909fa52745976b4c2d4e6010646bd3
• Download URL:
  https://stacks.cdc.gov/view/cdc/81157/cdc_81157_DS1.pdf
• File Type:
  [PDF - 2.00 MB ]